3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid

Base Information

Chemical Name:3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid
CAS No.:1263265-95-7
Molecular Formula:C₂₈H₃₉N₃O₅S
Molecular Weight:529.701
Hs Code.:

Synonyms:3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid

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Chemical Property of 3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid

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Technology Process of 3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid

There total 5 articles about 3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263265-94-6
tert-butyl 3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoate

: 1263265-95-7
3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 18h;

Reference yield:

: 19806-17-8
1,3-benzenediacetic acid

: 1263265-95-7
3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / 2-methyltetrahydrofuran / 19.5 h / 31 - 50 °C

2: hydrogen bromide / toluene; water / 38 h / 87 °C / Reflux

3: potassium carbonate / acetonitrile; water / 66 h / 20 - 60 °C

4: N-benzyl-trimethylammonium hydroxide / acetonitrile; water / 1 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 18 h

With lithium aluminium tetrahydride; hydrogen bromide; N-benzyl-trimethylammonium hydroxide; potassium carbonate; trifluoroacetic acid; In 2-methyltetrahydrofuran; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 46133-05-5
1,3-Bis(2'-hydroxyethyl)benzene

: 1263265-95-7
3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide / toluene; water / 38 h / 87 °C / Reflux

2: potassium carbonate / acetonitrile; water / 66 h / 20 - 60 °C

3: N-benzyl-trimethylammonium hydroxide / acetonitrile; water / 1 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 18 h

With hydrogen bromide; N-benzyl-trimethylammonium hydroxide; potassium carbonate; trifluoroacetic acid; In dichloromethane; water; toluene; acetonitrile;