α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

Base Information

Chemical Name:α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide
CAS No.:374791-63-6
Molecular Formula:C₂₄H₂₃F₆NO₂
Molecular Weight:471.443
Hs Code.:

Synonyms:α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

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Chemical Property of α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

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Technology Process of α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

There total 4 articles about α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 289686-69-7
2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

: 374794-41-9
4-Oxo-1-phenylcyclohexylamine Hydrochloride

: 374791-63-6
α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

Guidance literature:: In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 95261-39-5
4-amino-4-phenylcyclohexan-1-one

: 289686-70-0
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

: 374791-63-6
α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0960-894X(02)00249-4

Reference yield:

: 75945-91-4
4-oxo-1-phenylcyclohexanecarboxylic acid

: 374791-63-6
α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: (PhO)2PON₃; Et₃N / toluene / 90 °C

1.2: aq. HCl / Heating

2.1: Et₃N; EDC; HOBt / dimethylformamide / 20 °C

With diphenyl phosphoryl azide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; toluene; 1.1: Curtius rearrangement;
DOI:10.1016/S0960-894X(02)00249-4