methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate

Base Information

• Chemical Name: methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate
• CAS No.: 334477-48-4
• Molecular Formula: C₁₃H₁₂F₆O₂
• Molecular Weight: 314.227
• Mol file: 334477-48-4.mol

Synonyms:methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate

Chemical Property of methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate

There total 2 articles about methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl [3,5-bis(trifluoromethyl)-phenyl]-acetate (95299-16-4) + methyl iodide (74-88-4) → methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate (334477-48-4)

Guidance literature:

methyl [3,5-bis(trifluoromethyl)-phenyl]-acetate; With sodium hydride; In DMF (N,N-dimethyl-formamide); for 0.166667h;

methyl iodide; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield: 90.0%

1-(3,5-bis(trifluoromethyl)phenyl)-2-bromo-2-methylpropan-1-one + trimethyl orthoformate (149-73-5) → methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate (334477-48-4)

Guidance literature:

With zinc dibromide; at 100 ℃; for 7h; Temperature; Inert atmosphere;

Reference yield: 100.0%

methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate (334477-48-4) → α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Guidance literature:

methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate; With lithium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 72h;

With hydrogenchloride; In water;

upstream raw materials:

methyl [3,5-bis(trifluoromethyl)-phenyl]-acetate

methyl iodide

trimethyl orthoformate

Downstream raw materials:

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine

α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

Refernces

• 1、 Young, Jonathan R.,Eid, Ronsar,Turner, Cherilyn,DeVita, Robert J.,Kurtz, Marc M.,Tsao, Kwei-Lan C.,Chicchi, Gary G.,Wheeldon, Alan,Carlson, Emma,Mills, Sander G.. "Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists". . p. 5310 - 5315. Retrieved 2008/03/11.
• 2、 -. "Cyclohexyl derivatives and their use as therapeutic agents". Page 22. . Retrieved 2010/02/03.