1-<(3,4-dichlorophenyl)acetyl>-N,N-dimethyl-2-piperidinemethanamine

Base Information

• Chemical Name: 1-<(3,4-dichlorophenyl)acetyl>-N,N-dimethyl-2-piperidinemethanamine
• CAS No.: 130497-36-8
• Molecular Formula: C₁₆H₂₂Cl₂N₂O
• Molecular Weight: 329.269
• Mol file: 130497-36-8.mol

Synonyms:1-<(3,4-dichlorophenyl)acetyl>-N,N-dimethyl-2-piperidinemethanamine

Chemical Property of 1-<(3,4-dichlorophenyl)acetyl>-N,N-dimethyl-2-piperidinemethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<(3,4-dichlorophenyl)acetyl>-N,N-dimethyl-2-piperidinemethanamine

There total 8 articles about 1-<(3,4-dichlorophenyl)acetyl>-N,N-dimethyl-2-piperidinemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-<(3,4-dichlorophenyl)acetyl>-2-piperidinecarboxaldehyde (125348-92-7) + dimethyl amine (124-40-3) → 1-<(3,4-dichlorophenyl)acetyl>-N,N-dimethyl-2-piperidinemethanamine (130497-36-8)

Guidance literature:

With hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; In methanol; for 72h; Ambient temperature;

DOI:10.1021/jm00081a009

Reference yield:

(2R,S)-2-dimethylaminomethyl piperidine (60717-51-3) + 2-(3,4-dichlorophenyl)acetyl chloride (6831-55-6) → 1-<(3,4-dichlorophenyl)acetyl>-N,N-dimethyl-2-piperidinemethanamine (130497-36-8)

Guidance literature:

With potassium carbonate; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/jm00105a061

Reference yield:

3,4-dichlorophenyl acetic acid (5807-30-7) → 1-<(3,4-dichlorophenyl)acetyl>-N,N-dimethyl-2-piperidinemethanamine (130497-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 1,1'-carbonyldiimidazole / 1.) acetonitrile, RT, 20 min, 2.) acetonitrile, RT, 6 h

2: 69 percent / CrO₃, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

3: 71 percent / 5N HCl, 3-Angstroem molecular sieves, NaBH₃CN / methanol / 72 h / Ambient temperature

With pyridine; chromium(VI) oxide; hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; 1,1'-carbonyldiimidazole; In methanol; dichloromethane;

DOI:10.1021/jm00081a009

upstream raw materials:

1-<(3,4-dichlorophenyl)acetyl>-2-piperidinecarboxaldehyde

dimethyl amine

(2R,S)-2-dimethylaminomethyl piperidine

2-(3,4-dichlorophenyl)acetyl chloride