(2S,4R)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine

Base Information

• Chemical Name: (2S,4R)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine
• CAS No.: 1176195-94-0
• Molecular Formula: C₂₂H₂₂N₂
• Molecular Weight: 314.43

Synonyms:(2S,4R)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine

Chemical Property of (2S,4R)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4R)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine

There total 7 articles about (2S,4R)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-2,4-diphenyl-2,3-dihydro-1H-1,5-benzo[b][1,4]diazepine (55626-14-7) → C22H22N2 + C22H22N2 + (2S,4S)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine (1176196-23-8) + (2S,4R)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine (1176195-94-0)

Guidance literature:

With 4-hydroxy-2,6-diphenyl-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide; diallyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; In chloroform; at -10 ℃; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.bmcl.2009.05.039

Reference yield:

1,2-diamino-benzene (95-54-5) → C22H22N2 + (2S,4S)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine (1176196-23-8) + (2S,4R)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine (1176195-94-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,3,5-trichloro-2,4,6-triazine / toluene / 10 h / 45 °C / Inert atmosphere

2: hydrogen; C₁₂H₁₀O₄P^(1-)*C₂₅H₃₁N₂O₂RuS⁽¹⁺⁾ / dichloromethane / 10 h / 40 °C / 38002.6 Torr / Autoclave; Glovebox

With 1,3,5-trichloro-2,4,6-triazine; C₁₂H₁₀O₄P^(1-)*C₂₅H₃₁N₂O₂RuS⁽¹⁺⁾; hydrogen; In dichloromethane; toluene;

DOI:10.1002/ejoc.201700236

Reference yield:

acetophenone (98-86-2) → C22H22N2 + (2S,4S)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine (1176196-23-8) + (2S,4R)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine (1176195-94-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,3,5-trichloro-2,4,6-triazine / toluene / 10 h / 45 °C / Inert atmosphere

2: hydrogen; C₁₂H₁₀O₄P^(1-)*C₂₅H₃₁N₂O₂RuS⁽¹⁺⁾ / dichloromethane / 10 h / 40 °C / 38002.6 Torr / Autoclave; Glovebox

With 1,3,5-trichloro-2,4,6-triazine; C₁₂H₁₀O₄P^(1-)*C₂₅H₃₁N₂O₂RuS⁽¹⁺⁾; hydrogen; In dichloromethane; toluene;

DOI:10.1002/ejoc.201700236

upstream raw materials:

2-methyl-2,4-diphenyl-2,3-dihydro-1H-1,5-benzo[b][1,4]diazepine

acetophenone

1,2-diamino-benzene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1176195-94-0 (2S,4R)-2-methyl-2,4-diphenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine

Send

Send

Metric Ton KG G Pound L ML

Send

Send