Mehyl-7-Azaindole-4-Carboxylate

Base Information

• Chemical Name: Mehyl-7-Azaindole-4-Carboxylate
• CAS No.: 351439-07-1
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• Mol file: 351439-07-1.mol

Synonyms:Methyl-1H-pyrrolo[2,3-b]pyridin-4-carboxylat;7-Azaindole-4-carboxlic acid methyl ester;Methyl azaindolecarboxylate;AC1Q42V9;AG-F-21066;

Chemical Property of Mehyl-7-Azaindole-4-Carboxylate

Chemical Property:

• Refractive Index: 1.648
• PKA: 12.68±0.40(Predicted)
• PSA: 54.98000
• Density: 1.324 g/cm³
• LogP: 1.34950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Methyl 7-azaindole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Mehyl-7-Azaindole-4-Carboxylate

There total 5 articles about Mehyl-7-Azaindole-4-Carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

methanol (67-56-1) + 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid (479553-01-0) → methyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate (351439-07-1)

Guidance literature:

With thionyl chloride; for 18h; Reflux;

DOI:10.1016/j.bioorg.2021.105185

Reference yield: 80.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 4-Iodo-1-acetyl-7-azaindole (443729-67-7) → methyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate (351439-07-1)

Guidance literature:

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 60 ℃; for 12h;

DOI:10.1055/s-2001-13366

Reference yield:

1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid (479553-01-0) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate (351439-07-1)

Guidance literature:

In methanol; hexane; dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2011.04.014

upstream raw materials:

methanol

carbon monoxide

4-Iodo-1-acetyl-7-azaindole

1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid

Downstream raw materials:

methyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylate

methyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate

methyl 6-phenyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylate

6-phenyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid

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