(1R,2R)-2-tert-butyldiphenylsilyloxymethyl-1-[1-(2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

Base Information

Chemical Name:(1R,2R)-2-tert-butyldiphenylsilyloxymethyl-1-[1-(2-vinylphenylamino)prop-2-en-1-yl]cyclopropane
CAS No.:1273298-78-4
Molecular Formula:C₃₁H₃₇NOSi
Molecular Weight:467.726
Hs Code.:

Synonyms:(1R,2R)-2-tert-butyldiphenylsilyloxymethyl-1-[1-(2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

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Chemical Property of (1R,2R)-2-tert-butyldiphenylsilyloxymethyl-1-[1-(2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

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Technology Process of (1R,2R)-2-tert-butyldiphenylsilyloxymethyl-1-[1-(2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

There total 1 articles about (1R,2R)-2-tert-butyldiphenylsilyloxymethyl-1-[1-(2-vinylphenylamino)prop-2-en-1-yl]cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 3867-18-3
2-vinylaniline

: 3536-96-7
vinylmagnesium chloride

: 408348-31-2
(1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane

: 1273298-78-4
(1R,2R)-2-tert-butyldiphenylsilyloxymethyl-1-[1-(2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

Guidance literature:: 2-vinylaniline; (1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane; In diethyl ether; at 20 ℃; for 10h; Molecular sieve; Inert atmosphere;

With boron trifluoride diethyl etherate; In diethyl ether; at -40 ℃; for 0.5h; Inert atmosphere;

vinylmagnesium chloride; In diethyl ether; at -40 - 0 ℃; Inert atmosphere;
DOI:10.1039/c0ob00597e

Reference yield: 85.0%

: 64-18-6
formic acid

: 1273298-78-4
(1R,2R)-2-tert-butyldiphenylsilyloxymethyl-1-[1-(2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

: 1273298-99-9
C₃₂H₃₇NO₂Si

Guidance literature:: formic acid; With acetic anhydride; at 60 ℃; for 3h; Inert atmosphere;

(1R,2R)-2-tert-butyldiphenylsilyloxymethyl-1-[1-(2-vinylphenylamino)prop-2-en-1-yl]cyclopropane; In tetrahydrofuran; at 0 - 60 ℃;
DOI:10.1039/c0ob00597e

Reference yield:

: 1273298-78-4
(1R,2R)-2-tert-butyldiphenylsilyloxymethyl-1-[1-(2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

: C₃₂H₃₇NO₂Si

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic anhydride / 3 h / 60 °C / Inert atmosphere

1.2: 0 - 60 °C

2.1: carbonylchlorohydridotris(triphenylphosphine)ruthenium (II) / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux; Inert atmosphere

With carbonylchlorohydridotris(triphenylphosphine)ruthenium (II); acetic anhydride; In 5,5-dimethyl-1,3-cyclohexadiene;
DOI:10.1039/c0ob00597e