4-(3-trifluoromethylphenyl)-4-oxo-3-(2-fluoropyridin-4-yl)-1-oxo-1-(N-carbobenzoxypiperidin-4-yl)butane

Base Information

Chemical Name:4-(3-trifluoromethylphenyl)-4-oxo-3-(2-fluoropyridin-4-yl)-1-oxo-1-(N-carbobenzoxypiperidin-4-yl)butane
CAS No.:188345-24-6
Molecular Formula:C₂₉H₂₆F₄N₂O₄
Molecular Weight:542.53
Hs Code.:

Synonyms:4-(3-trifluoromethylphenyl)-4-oxo-3-(2-fluoropyridin-4-yl)-1-oxo-1-(N-carbobenzoxypiperidin-4-yl)butane

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Chemical Property of 4-(3-trifluoromethylphenyl)-4-oxo-3-(2-fluoropyridin-4-yl)-1-oxo-1-(N-carbobenzoxypiperidin-4-yl)butane

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Technology Process of 4-(3-trifluoromethylphenyl)-4-oxo-3-(2-fluoropyridin-4-yl)-1-oxo-1-(N-carbobenzoxypiperidin-4-yl)butane

There total 3 articles about 4-(3-trifluoromethylphenyl)-4-oxo-3-(2-fluoropyridin-4-yl)-1-oxo-1-(N-carbobenzoxypiperidin-4-yl)butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 188345-23-5
2-(2-Fluoropyridin-4-yl)-1-(3-trifluoromethylphenyl)-ethanone

: 85475-10-1
4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester

: 188345-24-6
4-(3-trifluoromethylphenyl)-4-oxo-3-(2-fluoropyridin-4-yl)-1-oxo-1-(N-carbobenzoxypiperidin-4-yl)butane

Guidance literature:: 2-(2-Fluoropyridin-4-yl)-1-(3-trifluoromethylphenyl)-ethanone; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester; In dimethyl sulfoxide; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2005.02.010

Reference yield:

: 461-87-0
2-fluoro-4-methylpyridine

: 188345-24-6
4-(3-trifluoromethylphenyl)-4-oxo-3-(2-fluoropyridin-4-yl)-1-oxo-1-(N-carbobenzoxypiperidin-4-yl)butane

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / -78 °C

2.1: NaH / dimethylsulfoxide / 0.5 h / 20 °C

2.2: dimethylsulfoxide / 18 h / 20 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2005.02.010

Reference yield:

: 116332-62-8
N-methoxy-N-methyl-3-trifluoromethylbenzamide

: 188345-24-6
4-(3-trifluoromethylphenyl)-4-oxo-3-(2-fluoropyridin-4-yl)-1-oxo-1-(N-carbobenzoxypiperidin-4-yl)butane

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / -78 °C

2.1: NaH / dimethylsulfoxide / 0.5 h / 20 °C

2.2: dimethylsulfoxide / 18 h / 20 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2005.02.010