2-benzoyloctanoic acid ethyl ester

Base Information

• Chemical Name: 2-benzoyloctanoic acid ethyl ester
• CAS No.: 118067-03-1
• Molecular Formula: C₁₇H₂₄O₃
• Molecular Weight: 276.376
• Mol file: 118067-03-1.mol

Synonyms:2-benzoyloctanoic acid ethyl ester

Chemical Property of 2-benzoyloctanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-benzoyloctanoic acid ethyl ester

There total 8 articles about 2-benzoyloctanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-bromo-hexane (111-25-1) + ethyl 3-oxo-3-phenylpropionate (94-02-0) → 2-benzoyloctanoic acid ethyl ester (118067-03-1)

Guidance literature:

With potassium carbonate; sodium iodide; at 65 ℃; for 360h;

Reference yield: 43.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) + 1-Iodohexane (638-45-9) → 2-benzoyloctanoic acid ethyl ester (118067-03-1)

Guidance literature:

ethyl 3-oxo-3-phenylpropionate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

1-Iodohexane; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/ejoc.201201194

Reference yield: 17.0%

diazoacetic acid ethyl ester (623-73-4) + Heptanophenone (1671-75-6) → 2-benzoyloctanoic acid ethyl ester (118067-03-1) + ethyl 3-oxo-2-phenylnonanoate + C17H24O3

Guidance literature:

Heptanophenone; With tetrafluoroboric acid diethyl ether; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere; Schlenk technique;

diazoacetic acid ethyl ester; In dichloromethane; at 20 ℃; for 72h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.0c02972

upstream raw materials:

1-bromo-hexane

ethyl 3-oxo-3-phenylpropionate

1-Iodohexane

acetophenone

Downstream raw materials:

ethyl 2-oxooctanoate

ethyl 2-benzoyl-2-hydroxyoctanoate

benzoic acid

4-hexyl-4-hydroxy-3-phenylisoxazoline-5-one

Refernces

• 1、 Bai, Feifei,Fang, Jianguo,Song, Zi-Long,Zhang, Baoxin. "Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes". . p. 2214 - 2231. Retrieved 2020/03/06.
• 2、 Wang, Chao,Li, Zhilong,Ju, Yeming,Koo, Sangho. "Mechanism and scope of the MnIII-initiated oxidation of β-ketocarbonyl compounds: Furan synthesis". . p. 6976 - 6985. Retrieved 2013/03/13.