1-O-benzyl-4,6-di-O-tert-butyldimethylsilyl-2-N,3-O-thiocarbonyl-α-L-sorbofuranosylamine

Base Information

Chemical Name:1-O-benzyl-4,6-di-O-tert-butyldimethylsilyl-2-N,3-O-thiocarbonyl-α-L-sorbofuranosylamine
CAS No.:575472-07-0
Molecular Formula:C₂₆H₄₅NO₅SSi₂
Molecular Weight:539.884
Hs Code.:

Synonyms:1-O-benzyl-4,6-di-O-tert-butyldimethylsilyl-2-N,3-O-thiocarbonyl-α-L-sorbofuranosylamine

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Chemical Property of 1-O-benzyl-4,6-di-O-tert-butyldimethylsilyl-2-N,3-O-thiocarbonyl-α-L-sorbofuranosylamine

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Technology Process of 1-O-benzyl-4,6-di-O-tert-butyldimethylsilyl-2-N,3-O-thiocarbonyl-α-L-sorbofuranosylamine

There total 5 articles about 1-O-benzyl-4,6-di-O-tert-butyldimethylsilyl-2-N,3-O-thiocarbonyl-α-L-sorbofuranosylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 575472-04-7
1-O-benzyl-2-N,3-O-thiocarbonyl-α-L-sorbofuranosylamine

: 575472-07-0
1-O-benzyl-4,6-di-O-tert-butyldimethylsilyl-2-N,3-O-thiocarbonyl-α-L-sorbofuranosylamine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0008-6215(03)00007-7

Reference yield:

: 35673-97-3
L-sorbose

: 575472-07-0
1-O-benzyl-4,6-di-O-tert-butyldimethylsilyl-2-N,3-O-thiocarbonyl-α-L-sorbofuranosylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 55 percent / H₂SO₄

2.1: 96 percent / NaH / dimethylformamide

3.1: TFA / H₂O

3.2: 78 percent / HCl / H₂O / 48 h / 50 °C

4.1: 85 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; sulfuric acid; sodium hydride; trifluoroacetic acid; In water; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(03)00007-7

Reference yield:

: 100-39-0
benzyl bromide

: 575472-07-0
1-O-benzyl-4,6-di-O-tert-butyldimethylsilyl-2-N,3-O-thiocarbonyl-α-L-sorbofuranosylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / NaH / dimethylformamide

2.1: TFA / H₂O

2.2: 78 percent / HCl / H₂O / 48 h / 50 °C

3.1: 85 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; sodium hydride; trifluoroacetic acid; In water; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(03)00007-7