N'-hydroxy-4-({2-[(4-methoxybenzyl)(methyl)amino]ethyl}amino)-1,2,5-oxadiazole-3-carboximidamide

Base Information

Chemical Name:N'-hydroxy-4-({2-[(4-methoxybenzyl)(methyl)amino]ethyl}amino)-1,2,5-oxadiazole-3-carboximidamide
CAS No.:1608129-04-9
Molecular Formula:C₁₄H₂₀N₆O₃
Molecular Weight:320.351
Hs Code.:

Synonyms:N'-hydroxy-4-({2-[(4-methoxybenzyl)(methyl)amino]ethyl}amino)-1,2,5-oxadiazole-3-carboximidamide

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Chemical Property of N'-hydroxy-4-({2-[(4-methoxybenzyl)(methyl)amino]ethyl}amino)-1,2,5-oxadiazole-3-carboximidamide

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Technology Process of N'-hydroxy-4-({2-[(4-methoxybenzyl)(methyl)amino]ethyl}amino)-1,2,5-oxadiazole-3-carboximidamide

There total 5 articles about N'-hydroxy-4-({2-[(4-methoxybenzyl)(methyl)amino]ethyl}amino)-1,2,5-oxadiazole-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1608129-03-8
4-amino-N'-hydroxy-N-(2-{[4-methoxybenzyl](methyl)amino}ethyl)-1,2,5-oxadiazole-3-carboximidamide

: 1608129-04-9
N'-hydroxy-4-({2-[(4-methoxybenzyl)(methyl)amino]ethyl}amino)-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: With potassium hydroxide; In ethylene glycol; at 135 ℃; for 2h;

Reference yield:

: 127780-69-2
2-((4-methoxybenzyl)(methyl)amino)acetonitrile

: 1608129-04-9
N'-hydroxy-4-({2-[(4-methoxybenzyl)(methyl)amino]ethyl}amino)-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - 20 °C

1.2: -10 °C

2.1: triethylamine / ethyl acetate; tetrahydrofuran / 1.5 h / 25 °C

3.1: potassium hydroxide / ethylene glycol / 2 h / 135 °C

With lithium aluminium tetrahydride; triethylamine; potassium hydroxide; In tetrahydrofuran; ethylene glycol; ethyl acetate;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1608129-04-9
N'-hydroxy-4-({2-[(4-methoxybenzyl)(methyl)amino]ethyl}amino)-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; water / methanol / 15 - 20 °C / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / toluene / 1 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - 20 °C

3.2: -10 °C

4.1: triethylamine / ethyl acetate; tetrahydrofuran / 1.5 h / 25 °C

5.1: potassium hydroxide / ethylene glycol / 2 h / 135 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; water; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethylene glycol; ethyl acetate; toluene;