(1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(methylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Base Information

Chemical Name:(1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(methylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide
CAS No.:1384958-74-0
Molecular Formula:C₃₅H₅₀N₄O₃Si
Molecular Weight:602.893
Hs Code.:

Synonyms:(1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(methylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Suppliers and Price of (1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(methylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(methylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(methylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

There total 11 articles about (1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(methylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1268163-51-4
tert-butyl (1E,4E)-4-((3-(tert-butyldimethylsilyloxy)propyl)(propyl)carbamoyl)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepin-2-ylcarbamate

: 74-89-5
methylamine

: 1384958-74-0
(1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(methylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 65 ℃; for 4.5h; sealed tube;

Reference yield:

: 389621-81-2
[4-(pyrrolidin-1-ylcarbonyl)phenyl]boronic acid

: 1384958-74-0
(1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(methylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 18 h / 100 °C

2.1: toluene / 2.5 h / Reflux

3.1: acetic acid; iron / 4 h / 20 - 85 °C

3.2: pH 9 - 10

4.1: dichloromethane / 72 h / 20 °C

5.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 30 h / 0 - 20 °C

5.2: pH 3.5

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.83 h / 20 °C

6.2: 1.5 h / 20 °C

7.1: triethylamine / N,N-dimethyl-formamide / 4.5 h / 65 °C / sealed tube

With iron; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 60956-26-5
4-bromo-2-nitrotoluene

: 1384958-74-0
(1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(methylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic anhydride; chromium(VI) oxide; sulfuric acid / 1 h / 0 - 10 °C

1.3: 0.75 h

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 18 h / 100 °C

3.1: toluene / 2.5 h / Reflux

4.1: acetic acid; iron / 4 h / 20 - 85 °C

4.2: pH 9 - 10

5.1: dichloromethane / 72 h / 20 °C

6.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 30 h / 0 - 20 °C

6.2: pH 3.5

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.83 h / 20 °C

7.2: 1.5 h / 20 °C

8.1: triethylamine / N,N-dimethyl-formamide / 4.5 h / 65 °C / sealed tube

With chromium(VI) oxide; sulfuric acid; acetic anhydride; iron; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;