N⁽⁶⁾-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-(benzotrizol-1-yl 2-chlorophenylphosphate)

Base Information

• Chemical Name: N⁽⁶⁾-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-(benzotrizol-1-yl 2-chlorophenylphosphate)
• CAS No.: 91592-78-8
• Molecular Formula: C₅₀H₄₂ClN₈O₉P
• Molecular Weight: 965.358
• Mol file: 91592-78-8.mol

Synonyms:N⁽⁶⁾-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-(benzotrizol-1-yl 2-chlorophenylphosphate)

Chemical Property of N⁽⁶⁾-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-(benzotrizol-1-yl 2-chlorophenylphosphate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁽⁶⁾-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-(benzotrizol-1-yl 2-chlorophenylphosphate)

There total 3 articles about N⁽⁶⁾-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-(benzotrizol-1-yl 2-chlorophenylphosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate (80817-46-5) + N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (64325-78-6) → N(6)-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-(benzotrizol-1-yl 2-chlorophenylphosphate) (91592-78-8)

Guidance literature:

In 1,4-dioxane; for 0.25h; Yield given; Ambient temperature;

DOI:10.1016/0040-4020(84)85104-2

Reference yield:

2-chlorophenyl dichlorophosphate (15074-54-1) → N(6)-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-(benzotrizol-1-yl 2-chlorophenylphosphate) (91592-78-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1,4-dioxane / 2 h

2: pyridine / 1,4-dioxane

With pyridine; In 1,4-dioxane;

DOI:10.1002/ejoc.201301352

Reference yield:

benzotriazol-1-ol (2592-95-2) → N(6)-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-(benzotrizol-1-yl 2-chlorophenylphosphate) (91592-78-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1,4-dioxane / 2 h

2: pyridine / 1,4-dioxane

With pyridine; In 1,4-dioxane;

DOI:10.1002/ejoc.201301352

upstream raw materials:

bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate

N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

benzotriazol-1-ol

2-chlorophenyl dichlorophosphate

Downstream raw materials:

C₆₈H₆₀ClN₁₀O₁₃P

Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

C₅₄H₅₁ClN₇O₁₃P

C₆₆H₅₈Cl₂N₁₀O₁₆P₂