(S)-t-butyl 4-(2-fluoro-4-(5-((methoxycarbonothioylamino)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: (S)-t-butyl 4-(2-fluoro-4-(5-((methoxycarbonothioylamino)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate
• CAS No.: 268208-30-6
• Molecular Formula: C₂₁H₂₉FN₄O₅S
• Molecular Weight: 468.549
• Mol file: 268208-30-6.mol

Synonyms:(S)-t-butyl 4-(2-fluoro-4-(5-((methoxycarbonothioylamino)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate

Chemical Property of (S)-t-butyl 4-(2-fluoro-4-(5-((methoxycarbonothioylamino)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-t-butyl 4-(2-fluoro-4-(5-((methoxycarbonothioylamino)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate

There total 2 articles about (S)-t-butyl 4-(2-fluoro-4-(5-((methoxycarbonothioylamino)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methanol (67-56-1) + (R)-t-butyl 4-(2-fluoro-4-(5-(isothiocyanatomethyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate (268209-50-3) → (S)-t-butyl 4-(2-fluoro-4-(5-((methoxycarbonothioylamino)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate (268208-30-6)

Guidance literature:

for 6h; Heating / reflux;

Reference yield:

methanol (67-56-1) + C20H26ClFN4O4S → (S)-t-butyl 4-(2-fluoro-4-(5-((methoxycarbonothioylamino)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate (268208-30-6)

Guidance literature:

In dichloromethane; Reflux;

DOI:10.1016/j.bmcl.2008.03.043

Reference yield: 37.04%

(S)-t-butyl 4-(2-fluoro-4-(5-((methoxycarbonothioylamino)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate (268208-30-6) + 4-chloro-benzoyl chloride (122-01-0) → (S)-S-methyl (3-(4-(4-(4-chloro-benzoyl-)-piperazin-1-yl)-3-fluoro-phenyl)-2-oxo-oxazoIidin-5-yl)-methyl-carbamothioate (1094622-73-7)

Guidance literature:

(S)-t-butyl 4-(2-fluoro-4-(5-((methoxycarbonothioylamino)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; for 12h;

4-chloro-benzoyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

upstream raw materials:

methanol

(R)-t-butyl 4-(2-fluoro-4-(5-(isothiocyanatomethyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate

Downstream raw materials:

{[(5S)-3-[3-fluoro-(1-piperazinyl)-phenyl]-2-oxo-5-oxazolidinyl]methyl}-carbamothioic acid methyl ester

(S)-S-methyl (3-(3-fluoro-4-(4-(morpholine-4-carbonothioyl)-piperazin-1-yl)-phenyl)-2-oxo-oxazoIidin-5-yl)-methyl-carbamothioate

(S)-S-methyl (3-(4-(4-(4-chloro-benzoyl-)-piperazin-1-yl)-3-fluoro-phenyl)-2-oxo-oxazoIidin-5-yl)-methyl-carbamothioate

(S)-S-methyl (3-(4-(4-(imidazo!e-1-carbonyl)-piperazin-1-yl)-3-fluoro-phenyl)-2-oxo-oxazoIidin-5-yl)-methyl-carbamothioate