{[(5S)-3-[3-fluoro-(1-piperazinyl)-phenyl]-2-oxo-5-oxazolidinyl]methyl}-carbamothioic acid methyl ester

Base Information

Chemical Name:{[(5S)-3-[3-fluoro-(1-piperazinyl)-phenyl]-2-oxo-5-oxazolidinyl]methyl}-carbamothioic acid methyl ester
CAS No.:268208-73-7
Molecular Formula:C₁₆H₂₁FN₄O₃S
Molecular Weight:368.432
Hs Code.:

Synonyms:{[(5S)-3-[3-fluoro-(1-piperazinyl)-phenyl]-2-oxo-5-oxazolidinyl]methyl}-carbamothioic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {[(5S)-3-[3-fluoro-(1-piperazinyl)-phenyl]-2-oxo-5-oxazolidinyl]methyl}-carbamothioic acid methyl ester

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Technology Process of {[(5S)-3-[3-fluoro-(1-piperazinyl)-phenyl]-2-oxo-5-oxazolidinyl]methyl}-carbamothioic acid methyl ester

There total 1 articles about {[(5S)-3-[3-fluoro-(1-piperazinyl)-phenyl]-2-oxo-5-oxazolidinyl]methyl}-carbamothioic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydrogen chloride ethyl acetate: hydrogen chloride ethyl acetate

: 268208-30-6
(S)-t-butyl 4-(2-fluoro-4-(5-((methoxycarbonothioylamino)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazine-1-carboxylate

: 144-55-8
sodium hydrogencarbonate

: 268208-73-7
{[(5S)-3-[3-fluoro-(1-piperazinyl)-phenyl]-2-oxo-5-oxazolidinyl]methyl}-carbamothioic acid methyl ester

Guidance literature:

Reference yield: 35.0%

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 268208-73-7
{[(5S)-3-[3-fluoro-(1-piperazinyl)-phenyl]-2-oxo-5-oxazolidinyl]methyl}-carbamothioic acid methyl ester

: 1094618-24-2
(S)-O-methyl (3-(4-(4-(1H-imidazoIe-1-carbonothioyI)-piperazin-1-yl)-3-fluorophenyl)-2-oxo-oxazoIidin-5-yl)-methyl-carbamothioate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield: 23.0%

: 100361-18-0
7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

: 268208-73-7
{[(5S)-3-[3-fluoro-(1-piperazinyl)-phenyl]-2-oxo-5-oxazolidinyl]methyl}-carbamothioic acid methyl ester

: 1-Cyclopropyl-6-fluoro-7-(4-{2-fluoro-4-[(S)-5-(methoxythiocarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-phenyl}-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

Guidance literature:: With chloro-trimethyl-silane; In dimethyl sulfoxide; at 150 ℃; for 10h; microwave irradiation;
DOI:10.1016/S0968-0896(03)00083-X