5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester
• CAS No.: 781663-70-5
• Molecular Formula: C₁₈H₁₇N₃O₄S
• Molecular Weight: 371.417

Synonyms:5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property of 5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

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Technology Process of 5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

There total 10 articles about 5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

potassium salt of ethyl 2-hydroxy-4-oxo-4-phenyl-2-butenoate + 4-aminosulfonylphenylhydrazine (4392-54-5) → 5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (781663-70-5)

Guidance literature:

potassium salt of ethyl 2-hydroxy-4-oxo-4-phenyl-2-butenoate; 4-aminosulfonylphenylhydrazine; In ethanol; at 20 ℃; for 1h; Inert atmosphere;

With acetic acid; In ethanol; for 2h; regioselective reaction; Reflux; Inert atmosphere;

DOI:10.1021/jm2001376

Reference yield: 83.0%

diethyl benzoylmethylphosphonate (3453-00-7) + C10H12ClN3O4S (96722-53-1) → 5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (781663-70-5)

Guidance literature:

With lithium hydroxide; In 1,2-dimethoxyethane; at 20 ℃; for 10h; regioselective reaction;

DOI:10.1016/j.tetlet.2013.12.045

Reference yield: 71.0%

ethyl 2,4-dioxo-4-phenylbutyrate (6296-54-4) + 4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0) → 5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (781663-70-5)

Guidance literature:

In ethanol; for 6h; Reflux;

DOI:10.1016/j.bioorg.2019.103222

upstream raw materials:

ethyl-(Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoate

4-aminosulfonylphenylhydrazine

acetophenone

4-hydrazinobenzene-1-sulfonamide hydrochloride

Downstream raw materials:

4-{5-phenyl-3-[3-(3-trifluoromethylphenyl)-ureido]-pyrazol-1-yl}-benzenesulfonamide

4-(3-azidomethyl-5-phenyl-pyrazol-1-yl)-benzenesulfonamide

4-{5-phenyl-3-[3-(3-trifluoromethylphenyl)-ureidomethyl]-pyrazol-1-yl}-benzenesulfonamide

4-[3-((E)-2-nitro-vinyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide

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