Fluoro(fluoromethoxy)methane

Base Information

• Chemical Name: Fluoro(fluoromethoxy)methane
• CAS No.: 462-51-1
• Molecular Formula: C2H4 F2 O
• Molecular Weight: 82.05
• Hs Code.: 2909199090
• DSSTox Substance ID: DTXSID10371091
• Nikkaji Number: J806.257I
• Wikidata: Q66084489
• Mol file: 462-51-1.mol

Synonyms:fluoro(fluoromethoxy)methane;462-51-1;Bis(fluoromethyl)ether;fluoromethyl ether;bis-(fluoromethyl)ether;bis(fluoromethyl) ether;fluoranyl(fluoranylmethoxy)methane;DTXSID10371091;MFCD00274309;AKOS006227994;FT-0623067;A827018

Chemical Property of Fluoro(fluoromethoxy)methane

Chemical Property:

• Vapor Pressure: 2360mmHg at 25°C
• Melting Point: -70°C
• Refractive Index: 1.27
• Boiling Point: 34°C
• Flash Point: °C
• PSA: 9.23000
• Density: 1.041g/cm³
• LogP: 0.85700
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 82.02302107
• Heavy Atom Count: 5
• Complexity: 15.1

Purity/Quality:

98%Min ^*data from raw suppliers

Bis(fluoromethyl)ether ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F
• Statements: 12
• Safety Statements: 3/7-9-16-29-33

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(OCF)F

Technology Process of Fluoro(fluoromethoxy)methane

There total 5 articles about Fluoro(fluoromethoxy)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.4%

dimethyl sulfoxide (67-68-5,8070-53-9) → difluoromethyl methyl sulfide (758-15-6) + methyl thio fluoroformate (2694-34-0) + bis(fluoromethyl)-ether (462-51-1) + fluoromethyl carbonofluoridate (2838-04-2)

Guidance literature:

With Carbonyl fluoride; for 12h; Yield given. Further byproducts given; Ambient temperature;

DOI:10.1016/S0022-1139(00)81144-6

Reference yield: 38.4%

Carbonyl fluoride (353-50-4) + dimethyl sulfoxide (67-68-5,8070-53-9) → difluoromethyl methyl sulfide (758-15-6) + methyl thio fluoroformate (2694-34-0) + bis(fluoromethyl)-ether (462-51-1) + fluoromethyl carbonofluoridate (2838-04-2)

Guidance literature:

for 12h; Yield given. Further byproducts given; Ambient temperature;

DOI:10.1016/S0022-1139(00)81144-6

Reference yield:

1,3,5-Trioxan (110-88-3) → bis(fluoromethyl)-ether (462-51-1)

Guidance literature:

With hydrogen fluoride; sulfuric acid; In dichloromethane; Polyethylene container; Cooling with ice;

upstream raw materials:

formaldehyd

Carbonyl fluoride

dimethyl sulfoxide

1,3,5-Trioxan

Downstream raw materials:

sevoflurane

difluoromethyl-fluoromethyl ether

bis(trifluoromethyl) ether

bis(difluoromethyl) ether

Refernces

• 1、 Darragh et al.. "". . p. 1745,1746. Retrieved 1970.