Technology Process of 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate
There total 10 articles about 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate;
In
1,4-dioxane;
at 20 - 100 ℃;
for 5.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / tetrahydrofuran; water / 4 h / 70 °C / Sealed tube
2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 40 °C
2.2: 20 h / 0 - 20 °C
3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 3.5 h / Reflux
4.1: acetic acid / 16 h / Reflux
5.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 5.5 h / 20 - 100 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium acetate; potassium carbonate; acetic acid;
In
tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: manganese(IV) oxide / dichloromethane / 12 h / 20 °C
2.1: hydroxylamine hydrochloride; triethylamine / ethanol / 2 h / Reflux
3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 40 °C
3.2: 20 h / 0 - 20 °C
4.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 3.5 h / Reflux
5.1: acetic acid / 16 h / Reflux
6.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 5.5 h / 20 - 100 °C / Inert atmosphere
With
manganese(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; potassium acetate; acetic acid; triethylamine;
In
1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
