1-benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide

Base Information

• Chemical Name: 1-benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide
• CAS No.: 845305-82-0
• Molecular Formula: Br*C₂₂H₂₉N₂O₃
• Molecular Weight: 449.388

Synonyms:1-benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide

Chemical Property of 1-benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide

There total 2 articles about 1-benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,1-dimethylethyl 4-(4'-pyridinyloxy)-1-piperidinecarboxylate (308386-35-8) + benzyl bromide (100-39-0) → 1-benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide (845305-82-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 4h;

DOI:10.1055/s-0028-1088154

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 1-benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide (845305-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 °C

2: dichloromethane / 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane;

Reference yield: 83.0%

1-benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide (845305-82-0) → tert-butyl 4-((1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)oxy)piperidine-1-carboxylate

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃; for 3h;

upstream raw materials:

1,1-dimethylethyl 4-(4'-pyridinyloxy)-1-piperidinecarboxylate

benzyl bromide

t-butyl 4-hydroxy piperidine-1-carboxylate

Downstream raw materials:

1,1-dimethylethyl 4-(4'-piperidinyloxy)-1-piperidinecarboxylate

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