1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanone

Base Information

• Chemical Name: 1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanone
• CAS No.: 617706-18-0
• Molecular Formula: C₈H₃BrF₄O
• Molecular Weight: 271.009
• Hs Code.: 2914790090
• Mol file: 617706-18-0.mol

Synonyms:1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one

Chemical Property of 1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanone

Chemical Property:

• Boiling Point: 237.1±40.0 °C(Predicted)
• Density: 1.717±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

4'-Bromo-2,2,2,2'-tetrafluoroacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanone

There total 4 articles about 1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethanol (1033805-88-7) → 1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one (617706-18-0)

Guidance literature:

With 2-iodoxybenzoic acid; In ethyl acetate; Reflux;

Reference yield:

1-[4-bromo-2-fluoro-3-(trimethylsilyl)phenyl]-2,2,2-trifluoroethanone → 1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one (617706-18-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1016/S0040-4039(03)01811-2

Reference yield:

3-fluorobromobenzene (1073-06-9) → 1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one (617706-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1.2: lithium 2,2,6,6-tetramethylpiperidine

2.1: Bu₄NF / tetrahydrofuran / 12 h / 20 °C

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(03)01811-2

upstream raw materials:

3-fluorobromobenzene

1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethanol

1-bromo-3-fluoro-2-(trimethylsilyl)benzene

Downstream raw materials:

(E)-1-(4-bromo-2-fluoro-phenyl)-2,2,2-trifluoro-ethanone oxime

6-bromo-3-(trifluoromethyl)-1H-indazole

2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-ol

3-{(Z)-1-fluoro-2-[3-fluoro-4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1H-pyrazole

Refernces

• 1、 -. "NOVEL 2,5-SUBSTITUTED PYRIMIDINES AS PDE4 INHIBITORS". Page/Page column 54. . Retrieved 2016/02/10.
• 2、 -. "3-(Fluorovinyl)pyrazoles and their use". Paragraph 0474; 0475; 0476; 0477. . Retrieved 2013/06/27.