2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-yl methanesulphonate

Base Information

Chemical Name:2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-yl methanesulphonate
CAS No.:1346689-94-8
Molecular Formula:C₁₀H₉BrF₄O₃S
Molecular Weight:365.143
Hs Code.:

Synonyms:2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-yl methanesulphonate

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Chemical Property of 2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-yl methanesulphonate

Chemical Property:

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Technology Process of 2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-yl methanesulphonate

There total 4 articles about 2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-yl methanesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346689-93-7
2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-ol

: 124-63-0
methanesulfonyl chloride

: 1346689-94-8
2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-yl methanesulphonate

Guidance literature:: 2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-ol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 - 40 ℃; for 1.5h;

methanesulfonyl chloride; In tetrahydrofuran; mineral oil; at 40 ℃; for 1h;

Reference yield:

: 617706-18-0
1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one

: 1346689-94-8
2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-yl methanesulphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane; n-heptane / 0.5 h / -30 °C

1.2: 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 20 - 40 °C

2.2: 1 h / 40 °C

With sodium hydride; In tetrahydrofuran; n-heptane; dichloromethane; mineral oil;

Reference yield:

: 1-[4-bromo-2-fluoro-3-(trimethylsilyl)phenyl]-2,2,2-trifluoroethanone

: 1346689-94-8
2-(4-bromo-2-fluorophenyl)-1,1,1-trifluoropropan-2-yl methanesulphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

2.1: dichloromethane; n-heptane / 0.5 h / -30 °C

2.2: 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 20 - 40 °C

3.2: 1 h / 40 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; n-heptane; dichloromethane; mineral oil;