(E)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-styryloxazole

Base Information

Chemical Name:(E)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-styryloxazole
CAS No.:1381778-72-8
Molecular Formula:C₁₈H₂₅NO₂Si
Molecular Weight:315.488
Hs Code.:

Synonyms:(E)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-styryloxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-styryloxazole

Chemical Property:

Purity/Quality:

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Technology Process of (E)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-styryloxazole

There total 2 articles about (E)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-styryloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 107367-72-6
4-hydroxymethyl-2-((E)-2-phenyl-1-ethenyl)-1,3-oxazole

: 1381778-72-8
(E)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-styryloxazole

Guidance literature:: With 1H-imidazole; In dichloromethane; toluene; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 132629-37-9
ethyl 2-[(E)-2-phenylethenyl]oxazole-4-carboxylate

: 1381778-72-8
(E)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-styryloxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

1.2: 24 h / 20 °C

2.1: 1H-imidazole / dichloromethane; toluene / 1 h / 20 °C / Inert atmosphere

With 1H-imidazole; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1381778-72-8
(E)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-styryloxazole

: 1381778-55-7
N-(2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium periodate; silica gel / ruthenium(III) trichloride hydrate / dichloromethane / 20 °C / Darkness; Inert atmosphere

2.1: dichloromethane; toluene / 0.75 h / 0 °C / Inert atmosphere

3.1: manganese(IV) oxide / acetonitrile / 20 °C / Inert atmosphere

4.1: dichloromethane; toluene / 1.5 h / 0 °C / Inert atmosphere

5.1: silver(l) oxide / dichloromethane / 40 °C / Inert atmosphere; Darkness

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

7.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 50 °C

9.1: ammonium chloride; iron / ethanol; water / 0.5 h / 85 °C / Inert atmosphere

10.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

10.2: 20 °C

With dmap; manganese(IV) oxide; sodium periodate; tetrabutyl ammonium fluoride; silica gel; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; silver(l) oxide; ruthenium(III) trichloride hydrate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;