N-{3-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Base Information

Chemical Name:N-{3-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide
CAS No.:1236404-94-6
Molecular Formula:C₂₉H₃₅N₃O₄
Molecular Weight:489.615
Hs Code.:

Synonyms:N-{3-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Chemical Property of N-{3-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Technology Process of N-{3-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

There total 10 articles about N-{3-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 586375-35-1
4-methylpiperidin-4-ol hydrochloride

: 1236405-08-5
N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

: 1236404-94-6
N-{3-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: 4-methylpiperidin-4-ol hydrochloride; N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide; With acetic acid; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 3h;

With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 3h;

With sodium hydroxide; In 1-methyl-pyrrolidin-2-one; water; Cooling with ice;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1236404-94-6
N-{3-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 14 h / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 20 °C

3.1: acetic acid / 1-methyl-pyrrolidin-2-one / 3 h / 20 °C

3.2: 3 h / 20 °C

3.3: Cooling with ice

With hydrogen; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;

Reference yield:

: 169750-57-6
benzyl 4-hydroxy-4-methylpiperidine-1-carboxylate

: 1236404-94-6
N-{3-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 20 °C

2.1: acetic acid / 1-methyl-pyrrolidin-2-one / 3 h / 20 °C

2.2: 3 h / 20 °C

2.3: Cooling with ice

With hydrogen; acetic acid; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; methanol;