2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)-5-methyl-phenoxy]-5-(trifluoromethyl)pyridine

Base Information

Chemical Name:2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)-5-methyl-phenoxy]-5-(trifluoromethyl)pyridine
CAS No.:1428929-32-1
Molecular Formula:C₂₂H₂₂F₃NO₃
Molecular Weight:405.417
Hs Code.:

Synonyms:2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)-5-methyl-phenoxy]-5-(trifluoromethyl)pyridine

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Chemical Property of 2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)-5-methyl-phenoxy]-5-(trifluoromethyl)pyridine

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Technology Process of 2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)-5-methyl-phenoxy]-5-(trifluoromethyl)pyridine

There total 8 articles about 2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)-5-methyl-phenoxy]-5-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1428929-31-0
2-[3-(diethoxyphosphorylmethyl)-5-methyl-phenoxy]-5-(trifluoromethyl)-pyridine

: 1428929-32-1
2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)-5-methyl-phenoxy]-5-(trifluoromethyl)pyridine

Guidance literature:: 2-[3-(diethoxyphosphorylmethyl)-5-methyl-phenoxy]-5-(trifluoromethyl)-pyridine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 4h;

cyclohexanedione monoethylene ketal; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 18h;

Reference yield:

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1428929-32-1
2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)-5-methyl-phenoxy]-5-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

2.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

3.1: 18 h / 130 °C

4.1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 0 - 20 °C

4.2: 18 h / 0 - 20 °C

With thionyl chloride; sodium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil; 4.1: |Wittig-Horner Reaction;

Reference yield:

: 1428929-79-6
ethoxycarbonyl 3-ethoxycarbonyloxy-5-methyl-benzoate

: 1428929-32-1
2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)-5-methyl-phenoxy]-5-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / methanol / 0.5 h / 20 °C

2.1: sodium hydroxide / ethanol; water / 1 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

4.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

5.1: 18 h / 130 °C

6.1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 0 - 20 °C

6.2: 18 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 6.1: |Wittig-Horner Reaction;