Benzeneacetaldehyde, 4-fluoro-alpha-methyl-, (+)- (9CI)

Base Information

• Chemical Name: Benzeneacetaldehyde, 4-fluoro-alpha-methyl-, (+)- (9CI)
• CAS No.: 305820-73-9
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.168
• Mol file: 305820-73-9.mol

Synonyms:Benzeneacetaldehyde, 4-fluoro-alpha-methyl-, (+)- (9CI)

Chemical Property of Benzeneacetaldehyde, 4-fluoro-alpha-methyl-, (+)- (9CI)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetaldehyde, 4-fluoro-alpha-methyl-, (+)- (9CI)

There total 18 articles about Benzeneacetaldehyde, 4-fluoro-alpha-methyl-, (+)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

p-fluoro-α-methylstyrene oxide (2967-83-1,235096-15-8) → 2-(4-fluorophenyl)propionaldehyde (189445-63-4,305820-73-9,549532-50-5)

Guidance literature:

With C₃₆H₅₄IrNP⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); In tetrahydrofuran; at 23 - 100 ℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/c4cc05260a

Reference yield: 92.0%

2-(4'-fluorophenyl)-1-methoxypropene (872045-32-4) → 2-(4-fluorophenyl)propionaldehyde (189445-63-4,305820-73-9,549532-50-5)

Guidance literature:

With hydrogen bromide; In water; acetone; at 0 ℃; for 24h;

DOI:10.1002/ejoc.200600654

Reference yield: 92.0%

para-fluorostyrene (405-99-2) + carbon monoxide (201230-82-2) → 2-(4-fluorophenyl)propionaldehyde (189445-63-4,305820-73-9,549532-50-5) + 3-(4-fluorophenyl)propanal (63416-70-6)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; sodium 4-dodecylbenzenesulfonate; Sodium; 2-[bis-(2-diphenylphosphanyl-ethyl)-carbamoyl]-benzenesulfonate; In water; toluene; at 60 ℃; under 30003 Torr;

DOI:10.1016/j.cclet.2021.07.068

upstream raw materials:

ethyl 3-(4-fluorophenyl)-3-methyloxirane-2-carboxylate

1-(4-fluorophenyl)ethanone

chloroacetic acid ethyl ester

para-fluorostyrene

Downstream raw materials:

(+/-)-4-(4-Fluor-phenyl)-pent-2-ensaeure

(R)-2-(4-fluorophenyl)-2-methyl-4,4-bis(phenylsulfonyl)butanal

(2R)-2-(4-fluorophenyl)propanoic acid

(S)-4-fluoro-α-methylphenylacetic acid

Refernces

• 1、 Rezayee, Nomaan M.,Enem?rke, Valdemar J.,Linde, Sif T.,Lamhauge, Johannes N.,Reyes-Rodríguez, Gabriel J.,J?rgensen, Karl Anker,Lu, Chenxi,Houk. "An Asymmetric SN2 Dynamic Kinetic Resolution". . p. 7509 - 7520. Retrieved 2021/05/26.
• 2、 Liu, Lei,Chen, Xiao-Chao,Yang, Shu-Qing,Yao, Yin-Qing,Lu, Yong,Liu, Ye. "Insight into decomposition of formic acid to syngas required for Rh-catalyzed hydroformylation of olefins". . p. 406 - 415. Retrieved 2020/12/07.