N-(2,2-dimethoxy-ethyl)-2-(acetyl-benzylamino)-3,3-dimethyl-thiobutyric acid amide

Base Information

• Chemical Name: N-(2,2-dimethoxy-ethyl)-2-(acetyl-benzylamino)-3,3-dimethyl-thiobutyric acid amide
• CAS No.: 866784-77-2
• Molecular Formula: C₁₉H₃₀N₂O₃S
• Molecular Weight: 366.525
• Mol file: 866784-77-2.mol

Synonyms:N-(2,2-dimethoxy-ethyl)-2-(acetyl-benzylamino)-3,3-dimethyl-thiobutyric acid amide

Chemical Property of N-(2,2-dimethoxy-ethyl)-2-(acetyl-benzylamino)-3,3-dimethyl-thiobutyric acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,2-dimethoxy-ethyl)-2-(acetyl-benzylamino)-3,3-dimethyl-thiobutyric acid amide

There total 4 articles about N-(2,2-dimethoxy-ethyl)-2-(acetyl-benzylamino)-3,3-dimethyl-thiobutyric acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(N-formylamino)acetaldehyde dimethyl acetal (135393-73-6) → N-(2,2-dimethoxy-ethyl)-2-(acetyl-benzylamino)-3,3-dimethyl-thiobutyric acid amide (866784-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / Et₃N; POCl₃ / CH₂Cl₂ / 1 h / 20 °C

2: methanol / 20 °C

With triethylamine; trichlorophosphate; In methanol; dichloromethane; 2: Ugi reaction;

DOI:10.1039/b507028g

Reference yield:

N-(2,2-dimethylpropylidene)benzylamine (1775-74-2) + tiolacetic acid (507-09-5) + isocyanoacetaldehyde dimethylacetale (277300-82-0) → N-(2,2-dimethoxy-ethyl)-2-(acetyl-benzylamino)-3,3-dimethyl-thiobutyric acid amide (866784-77-2)

Guidance literature:

In methanol; at 20 ℃;

DOI:10.1039/b507028g

Reference yield:

pivalaldehyde (630-19-3) → N-(2,2-dimethoxy-ethyl)-2-(acetyl-benzylamino)-3,3-dimethyl-thiobutyric acid amide (866784-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 0.25 h / 20 °C

2: methanol / 20 °C

In methanol; ethanol; 2: Ugi reaction;

DOI:10.1039/b507028g

upstream raw materials:

N-(2,2-dimethylpropylidene)benzylamine

tiolacetic acid

isocyanoacetaldehyde dimethylacetale

(N-formylamino)acetaldehyde dimethyl acetal