ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate

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Chemical Name:ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate
CAS No.:1352835-08-5
Molecular Formula:C₃₂H₃₁N₃O₆
Molecular Weight:553.615
Hs Code.:

Synonyms:ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate

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Chemical Property of ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate

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Technology Process of ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate

There total 9 articles about ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.8%

: 924-44-7
glyoxylic acid ethyl ester

: 1352835-07-4
benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-methylphenylcarbamate

: 1352835-08-5
ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: glyoxylic acid ethyl ester; benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-methylphenylcarbamate; With hydrogenchloride; In 1,4-dioxane; toluene; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In water; pH=10;

With oxygen; palladium 10% on activated carbon; In para-xylene; at 125 ℃; for 4.5h;

Reference yield:

: 2380-86-1
6-hydroxy-1H-indole

: 1352835-08-5
ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C

2.1: tetrahydrofuran / 16 h / 125 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 4.5 h / 20 °C

4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C

4.2: pH 10

4.3: 4.5 h / 125 °C

With hydrogenchloride; ammonium chloride; caesium carbonate; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 69022-35-1
2-methyl-3-amino-benzonitrile

: 1352835-08-5
ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

2.2: 0.5 h / 20 °C / Cooling with ice

3.1: ammonium acetate; acetic acid / 4.5 h / 90 °C

4.1: tetrahydrofuran / 16 h / 125 °C

5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 4.5 h / 20 °C

6.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C

6.2: pH 10

6.3: 4.5 h / 125 °C

With hydrogenchloride; ammonium acetate; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;