N-((R)-ethylphenylphosphinyl)-N-benzyl D-alanine methyl ester

Base Information

• Chemical Name: N-((R)-ethylphenylphosphinyl)-N-benzyl D-alanine methyl ester
• CAS No.: 204275-16-1
• Molecular Formula: C₁₉H₂₄NO₃P
• Molecular Weight: 345.378
• Mol file: 204275-16-1.mol

Synonyms:N-((R)-ethylphenylphosphinyl)-N-benzyl D-alanine methyl ester

Chemical Property of N-((R)-ethylphenylphosphinyl)-N-benzyl D-alanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((R)-ethylphenylphosphinyl)-N-benzyl D-alanine methyl ester

There total 3 articles about N-((R)-ethylphenylphosphinyl)-N-benzyl D-alanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

ethylphenylphosphinic chloride (1499-22-5) + N-benzyl D-alanine methyl ester (120571-58-6) → N-((S)-ethylphenylphosphinyl)-N-benzyl D-alanine methyl ester (204275-15-0) + N-((R)-ethylphenylphosphinyl)-N-benzyl D-alanine methyl ester (204275-16-1)

Guidance literature:

With 4-methyl-morpholine; dmap; In dichloromethane; for 90h; Ambient temperature;

DOI:10.1021/jm980142s

Reference yield:

ethylphenylphosphinic acid ethyl ester (2227-43-2) → N-((R)-ethylphenylphosphinyl)-N-benzyl D-alanine methyl ester (204275-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / benzene / 3 h / Ambient temperature

2: 41 percent / N-methylmorpholine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 90 h / Ambient temperature

With 4-methyl-morpholine; dmap; oxalyl dichloride; In dichloromethane; benzene;

DOI:10.1021/jm980142s

Reference yield:

diethyl phenylphosphonite (1638-86-4) → N-((R)-ethylphenylphosphinyl)-N-benzyl D-alanine methyl ester (204275-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1: benzene / 60 h / 85 °C

2: oxalyl chloride / benzene / 3 h / Ambient temperature

3: 41 percent / N-methylmorpholine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 90 h / Ambient temperature

With 4-methyl-morpholine; dmap; oxalyl dichloride; In dichloromethane; benzene;

DOI:10.1021/jm980142s

upstream raw materials:

ethylphenylphosphinic chloride

N-benzyl D-alanine methyl ester

ethylphenylphosphinic acid ethyl ester

diethyl phenylphosphonite