4-Methoxy-alpha-(2-methylphenyl)benzenemethanol

Base Information

• Chemical Name: 4-Methoxy-alpha-(2-methylphenyl)benzenemethanol
• CAS No.: 220583-41-5
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.291
• DSSTox Substance ID: DTXSID501264222
• Nikkaji Number: J3.498.667C
• Mol file: 220583-41-5.mol

Synonyms:DTXSID501264222;AKOS010016145;J3.498.667C;4-Methoxy-alpha-(2-methylphenyl)benzenemethanol;alpha-(2-Methylphenyl)-4-methoxybenzyl alcohol;220583-41-5

Chemical Property of 4-Methoxy-alpha-(2-methylphenyl)benzenemethanol

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 228.115029749
• Heavy Atom Count: 17
• Complexity: 221

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=CC=C1C(C2=CC=C(C=C2)OC)O

Technology Process of 4-Methoxy-alpha-(2-methylphenyl)benzenemethanol

There total 5 articles about 4-Methoxy-alpha-(2-methylphenyl)benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Methylphenylboronic acid (16419-60-6) + 4-methoxy-benzaldehyde (123-11-5) → 4-methoxyphenyl(2-methylphenyl)methanol (220583-41-5)

Guidance literature:

With tri-tert-butyl phosphine; {rhodium(acetylacetonate)(cis-cyclooctene)2}; In 1,2-dimethoxyethane; water; at 25 - 28 ℃; for 16h;

DOI:10.1021/jo000187c

Reference yield: 79.0%

1-bromo-4-methoxy-benzene (104-92-7) + 2-methylphenyl aldehyde (529-20-4) → 4-methoxyphenyl(2-methylphenyl)methanol (220583-41-5)

Guidance literature:

With nickel(II) bromide 2-methoxyethyl ether complex; 4,4'-di-tert-butyl-2,2'-bipyridine; zinc; In tetrahydrofuran; at 60 ℃; for 16h; Sealed tube; Inert atmosphere;

DOI:10.1021/jacs.8b13709

Reference yield:

C19H23NO2S + 3-phenyl-5H-1,4,2-dioxazol-5-one (19226-36-9) → C22H18N2O + 4-methoxyphenyl(2-methylphenyl)methanol (220583-41-5)

Guidance literature:

C₁₉H₂₃NO₂S; 3-phenyl-5H-1,4,2-dioxazol-5-one; With carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; silver(I) triflimide; In 1,2-dichloro-ethane; at 120 ℃; for 16h; Inert atmosphere; Sealed tube;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.6b00227

upstream raw materials:

2-Methylphenylboronic acid

4-methoxy-benzaldehyde

(4-methoxyphenyl)(2-methylphenyl)methanone

3-phenyl-5H-1,4,2-dioxazol-5-one

Downstream raw materials:

(4-methoxyphenyl)(2-methylphenyl)methanone