5-benzyloxy-1,3-dibromo-2-[1-(4-methoxy-phenyl)-2-nitro-ethyl]-benzene

Base Information

Chemical Name:5-benzyloxy-1,3-dibromo-2-[1-(4-methoxy-phenyl)-2-nitro-ethyl]-benzene
CAS No.:1269631-59-5
Molecular Formula:C₂₂H₁₉Br₂NO₄
Molecular Weight:521.205
Hs Code.:

Synonyms:5-benzyloxy-1,3-dibromo-2-[1-(4-methoxy-phenyl)-2-nitro-ethyl]-benzene

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Chemical Property of 5-benzyloxy-1,3-dibromo-2-[1-(4-methoxy-phenyl)-2-nitro-ethyl]-benzene

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Technology Process of 5-benzyloxy-1,3-dibromo-2-[1-(4-methoxy-phenyl)-2-nitro-ethyl]-benzene

There total 2 articles about 5-benzyloxy-1,3-dibromo-2-[1-(4-methoxy-phenyl)-2-nitro-ethyl]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 3179-10-0,5576-97-6
(E)-1-methoxy-4-(2-nitrovinyl)benzene

: 556038-43-8
3,5-dibromo-4-iodophenol benzyl ether

: 1269631-59-5
5-benzyloxy-1,3-dibromo-2-[1-(4-methoxy-phenyl)-2-nitro-ethyl]-benzene

Guidance literature:: 3,5-dibromo-4-iodophenol benzyl ether; With n-butyllithium; In hexane; toluene; at -74 ℃;

(E)-1-methoxy-4-(2-nitrovinyl)benzene; In hexane; toluene; at -78 ℃; for 2.5h;
DOI:10.1002/asia.201000544

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1269631-59-5
5-benzyloxy-1,3-dibromo-2-[1-(4-methoxy-phenyl)-2-nitro-ethyl]-benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / 4 h / 20 °C / Reflux

2.1: n-butyllithium / hexane; toluene / -74 °C

2.2: 2.5 h / -78 °C

With n-butyllithium; ammonium acetate; acetic acid; In hexane; toluene;
DOI:10.1002/asia.201000544

Reference yield:

: 1269631-59-5
5-benzyloxy-1,3-dibromo-2-[1-(4-methoxy-phenyl)-2-nitro-ethyl]-benzene

: 1269631-64-2
6-benzyloxy-3-(4-methoxy-phenyl)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; iron; iron(II) chloride / ethanol / 8 h / Reflux

2.1: sodium hydrogencarbonate / dichloromethane; water / 15 h / 20 °C

3.1: copper(l) iodide; cesium acetate / dimethyl sulfoxide / 21 h / 20 °C

4.1: caesium carbonate; thiophenol / acetonitrile / 3 h / 20 °C

5.1: 0.25 h / 100 °C

6.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether; hexane / 1 h / -78 °C

6.2: 1.5 h / -78 - 20 °C

With hydrogenchloride; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; cesium acetate; iron; sodium hydrogencarbonate; caesium carbonate; thiophenol; iron(II) chloride; In diethyl ether; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/asia.201000544