5-(6-chloro-2,4-dimethoxypyrimidin-5-yl)-5-oxopentanyl dibenzyl phosphate

Base Information

Chemical Name:5-(6-chloro-2,4-dimethoxypyrimidin-5-yl)-5-oxopentanyl dibenzyl phosphate
CAS No.:952410-50-3
Molecular Formula:C₂₅H₂₈ClN₂O₇P
Molecular Weight:534.933
Hs Code.:

Synonyms:5-(6-chloro-2,4-dimethoxypyrimidin-5-yl)-5-oxopentanyl dibenzyl phosphate

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Chemical Property of 5-(6-chloro-2,4-dimethoxypyrimidin-5-yl)-5-oxopentanyl dibenzyl phosphate

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Technology Process of 5-(6-chloro-2,4-dimethoxypyrimidin-5-yl)-5-oxopentanyl dibenzyl phosphate

There total 3 articles about 5-(6-chloro-2,4-dimethoxypyrimidin-5-yl)-5-oxopentanyl dibenzyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.6%

: 6320-15-6
6-chloro-2,4-dimethoxypyrimidine

: 474644-31-0
ethyl 5-[bis(benzyloxy)phosphoryloxy]pentanoate

: 952410-50-3
5-(6-chloro-2,4-dimethoxypyrimidin-5-yl)-5-oxopentanyl dibenzyl phosphate

Guidance literature:: 6-chloro-2,4-dimethoxypyrimidine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

ethyl 5-[bis(benzyloxy)phosphoryloxy]pentanoate; In tetrahydrofuran; at -78 - -40 ℃; Further stages.;
DOI:10.1021/jo070982r

Reference yield:

: 50651-75-7
silver dibenzylphosphate

: 952410-50-3
5-(6-chloro-2,4-dimethoxypyrimidin-5-yl)-5-oxopentanyl dibenzyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 60 percent / toluene / 24 h / Heating

2.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 25.6 percent / tetrahydrofuran / -78 - -40 °C

With n-butyllithium; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo070982r

Reference yield:

: 14660-52-7
ethyl 5-bromovalerate

: 952410-50-3
5-(6-chloro-2,4-dimethoxypyrimidin-5-yl)-5-oxopentanyl dibenzyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 60 percent / toluene / 24 h / Heating

2.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 25.6 percent / tetrahydrofuran / -78 - -40 °C

With n-butyllithium; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo070982r