methyl ({[(4R)-1,3-dibenzyl-5-methoxy-2-oxo-imidazolidin-4-yl]methyl}thio)acetate

Base Information

Chemical Name:methyl ({[(4R)-1,3-dibenzyl-5-methoxy-2-oxo-imidazolidin-4-yl]methyl}thio)acetate
CAS No.:866467-72-3
Molecular Formula:C₂₂H₂₆N₂O₄S
Molecular Weight:414.525
Hs Code.:

Synonyms:methyl ({[(4R)-1,3-dibenzyl-5-methoxy-2-oxo-imidazolidin-4-yl]methyl}thio)acetate

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Chemical Property of methyl ({[(4R)-1,3-dibenzyl-5-methoxy-2-oxo-imidazolidin-4-yl]methyl}thio)acetate

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Technology Process of methyl ({[(4R)-1,3-dibenzyl-5-methoxy-2-oxo-imidazolidin-4-yl]methyl}thio)acetate

There total 5 articles about methyl ({[(4R)-1,3-dibenzyl-5-methoxy-2-oxo-imidazolidin-4-yl]methyl}thio)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 866467-71-2
(3S,7aR)-6-benzyl-7-methoxy-3-phenyltetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one

: 96-34-4
methyl chloroacetate

: 866467-72-3
methyl ({[(4R)-1,3-dibenzyl-5-methoxy-2-oxo-imidazolidin-4-yl]methyl}thio)acetate

Guidance literature:: (3S,7aR)-6-benzyl-7-methoxy-3-phenyltetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one; With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 0.5h; Heating;

methyl chloroacetate; With potassium carbonate; In acetone; at 20 ℃;
DOI:10.1016/j.tet.2005.07.070

Reference yield:

: 112878-92-9
(3S,7aR)-6-benzyl-3-phenyldihydro-3H,5H-imidazo[1,5-c]thiazole-5,7(6H)-dione

: 866467-72-3
methyl ({[(4R)-1,3-dibenzyl-5-methoxy-2-oxo-imidazolidin-4-yl]methyl}thio)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / sodium borohydride / methanol / 0 - 20 °C

2.1: 99 percent / p-TSA / methanol / 0.17 h / 20 °C

3.1: tri-n-butyltin hydride; AIBN / benzene / 0.5 h / Heating

3.2: 80 percent / anhydrous potassium carbonate / acetone / 20 °C

With sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; toluene-4-sulfonic acid; In methanol; benzene;
DOI:10.1016/j.tet.2005.07.070

Reference yield:

: 848302-22-7
(3S,7aR)-6-benzyl-7-hydroxy-3-phenyltetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one

: 866467-72-3
methyl ({[(4R)-1,3-dibenzyl-5-methoxy-2-oxo-imidazolidin-4-yl]methyl}thio)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / p-TSA / methanol / 0.17 h / 20 °C

2.1: tri-n-butyltin hydride; AIBN / benzene / 0.5 h / Heating

2.2: 80 percent / anhydrous potassium carbonate / acetone / 20 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; toluene-4-sulfonic acid; In methanol; benzene;
DOI:10.1016/j.tet.2005.07.070