866467-71-2Relevant articles and documents
An unusual stereochemical outcome of radical cyclization: Synthesis of (+)-biotin
Chavan, Subhash P.,Chittiboyina, Amar G.,Ramakrishna, Guduru,Tejwani, Rajkumar B.,Ravindranathan,Kamat, Subhash K.,Rai, Beena,Sivadasan, Latha,Balakrishnan, Kamalam,Ramalingam,Deshpande
, p. 9273 - 9280 (2005)
An enantioselective synthesis of (+)-biotin 1 starting from naturally available cysteine is described. The key steps are the unusual stereochemical outcome of radical cyclization of compound 10 to prepare 5,5-fused system 11, and the introduction of C4-sidechain at C6 in 13 via a Grignard reaction.
7 - alkoxy -3 - phenyl tetrahydroimidazo [1,5 - c] thiazole -5 (1H) - method for preparing compound of
-
Paragraph 0045-0050; 0087-0088, (2020/02/10)
The invention discloses a preparation method of a 7-alkoxy-3-phenyltetrahydroimidazo[1,5-c]thiazole-5(1H)-one compound. The method comprises the following steps: sequentially reacting a dihydroimidazo[1,5-c]-thiazole-5,7(3H,6H)-dione compound with zinc po