p-nitro-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine

Base Information

• Chemical Name: p-nitro-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine
• CAS No.: 1610930-38-5
• Molecular Formula: C₁₉H₃₅N₃O₄Si₂
• Molecular Weight: 425.676
• Mol file: 1610930-38-5.mol

Synonyms:p-nitro-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine

Chemical Property of p-nitro-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-nitro-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine

There total 1 articles about p-nitro-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.3%

O-(tert-butyldimethylsilanyl)hydroxylamine (41879-39-4) + 4-nitrobenzohydroximoyl chloride (1011-84-3) → p-nitro-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine (1610930-38-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 240h;

DOI:10.1016/j.tetlet.2014.04.048

Reference yield: 23.0%

p-nitro-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine (1610930-38-5) → p-amino-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine (1610930-41-0)

Guidance literature:

With sodium dithionite; In tetrahydrofuran; water; at 20 ℃; for 5h;

DOI:10.1016/j.tetlet.2014.04.048

Reference yield:

p-nitro-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine (1610930-38-5) → p-aminobenzamidine (3858-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium dithionite / tetrahydrofuran; water / 5 h / 20 °C

2: 5%-palladium/activated carbon; palladium / 10 h / 1520.1 Torr

With sodium dithionite; 5%-palladium/activated carbon; palladium; In tetrahydrofuran; water;

DOI:10.1016/j.tetlet.2014.04.048

upstream raw materials:

O-(tert-butyldimethylsilanyl)hydroxylamine

4-nitrobenzohydroximoyl chloride

Downstream raw materials:

p-aminobenzamidine

p-amino-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine

p-amino-N,N'-dihydroxybenzamidine

Refernces