methyl N-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)methyl]-N-methylglycinate

Base Information

Chemical Name:methyl N-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)methyl]-N-methylglycinate
CAS No.:1334608-27-3
Molecular Formula:C₂₈H₃₂N₄O₂
Molecular Weight:456.588
Hs Code.:

Synonyms:methyl N-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)methyl]-N-methylglycinate

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Chemical Property of methyl N-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)methyl]-N-methylglycinate

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Technology Process of methyl N-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)methyl]-N-methylglycinate

There total 8 articles about methyl N-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)methyl]-N-methylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5473-12-1
N-methylglycine methylester

: 1334608-10-4
5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile

: 1334608-27-3
methyl N-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)methyl]-N-methylglycinate

Guidance literature:: N-methylglycine methylester; 5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile; With acetic acid; In dichloromethane; at 20 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 134604-07-2
2-bromo-5-nitrobenzonitrile

: 1334608-27-3
methyl N-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)methyl]-N-methylglycinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 16 h / 100 °C / Inert atmosphere

2.1: zinc; water; ammonium formate / methanol / 4 h / 80 °C

3.1: sodium nitrite; hydrogen bromide / acetonitrile / 0.5 h / 0 °C

3.2: 16 h / 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 130 °C / Inert atmosphere; Sealed; Biotage Initiator

6.1: acetic acid / dichloromethane / 0.25 h / 20 °C

6.2: 3 h / 20 °C

With potassium phosphate; water; hydrogen bromide; ammonium formate; potassium acetate; caesium carbonate; acetic acid; zinc; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 288251-97-8
5-amino-2-(2-methylpropyl)benzonitrile

: 1334608-27-3
methyl N-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)methyl]-N-methylglycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; hydrogen bromide / acetonitrile / 0.5 h / 0 °C

1.2: 16 h / 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 130 °C / Inert atmosphere; Sealed; Biotage Initiator

4.1: acetic acid / dichloromethane / 0.25 h / 20 °C

4.2: 3 h / 20 °C

With potassium phosphate; hydrogen bromide; potassium acetate; acetic acid; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;