(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol

Base Information

Chemical Name:(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol
CAS No.:1312605-92-7
Molecular Formula:C₁₆H₁₃FN₂O₃S
Molecular Weight:332.355
Hs Code.:

Synonyms:(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol

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Chemical Property of (7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol

Chemical Property:

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Technology Process of (7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol

There total 11 articles about (7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312605-91-6
Methyl-7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate

: 1312605-92-7
(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol

Guidance literature:: Methyl-7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 4h;

With ammonium chloride; In dichloromethane;

Reference yield:

: 652160-72-0
2-bromo-5-fluoro-3-nitropyridine

: 1312605-92-7
(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 8 steps

1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere

2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; tetrahydrofuran / 6 h / 25 °C

3: sodium periodate; water / tert-butyl alcohol; tetrahydrofuran / 8 h / 25 °C

4: toluene-4-sulfonic acid / toluene / 25 - 120 °C

5: hydrogen / palladium on carbon / ethanol / 25 °C / Inert atmosphere

6: water; lithium chloride / dimethyl sulfoxide / 16 h / 90 °C

7: cerium(III) chloride heptahydrate / 3 h / 100 °C

8: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C

With sodium periodate; osmium(VIII) oxide; cerium(III) chloride heptahydrate; water; hydrogen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium on carbon; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; toluene; tert-butyl alcohol;

Reference yield:

: 1289047-69-3
5-fluoro-3-nitropicolinaldehyde

: 1312605-92-7
(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 25 - 120 °C

2: hydrogen / palladium on carbon / ethanol / 25 °C / Inert atmosphere

3: water; lithium chloride / dimethyl sulfoxide / 16 h / 90 °C

4: cerium(III) chloride heptahydrate / 3 h / 100 °C

5: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C

With cerium(III) chloride heptahydrate; water; hydrogen; diisobutylaluminium hydride; lithium chloride; palladium on carbon; toluene-4-sulfonic acid; In ethanol; dichloromethane; dimethyl sulfoxide; toluene;