methyl 2-<(trimethylsilyl)methyl>amino-2-(4-fluorophenyl)acetate

Base Information

• Chemical Name: methyl 2-<(trimethylsilyl)methyl>amino-2-(4-fluorophenyl)acetate
• CAS No.: 220437-99-0
• Molecular Formula: C₁₃H₂₀FNO₂Si
• Molecular Weight: 269.391
• Mol file: 220437-99-0.mol

Synonyms:methyl 2-<(trimethylsilyl)methyl>amino-2-(4-fluorophenyl)acetate

Chemical Property of methyl 2-<(trimethylsilyl)methyl>amino-2-(4-fluorophenyl)acetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 2-<(trimethylsilyl)methyl>amino-2-(4-fluorophenyl)acetate

There total 1 articles about methyl 2-<(trimethylsilyl)methyl>amino-2-(4-fluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

dl-α-4-fluorophenylglycine methyl ester hydrochloride (42718-18-3) + Chloromethyltrimethylsilane (2344-80-1) → methyl 2-<(trimethylsilyl)methyl>amino-2-(4-fluorophenyl)acetate (220437-99-0)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

DOI:10.1021/jo981729h

Reference yield: 95.0%

methyl 2-<(trimethylsilyl)methyl>amino-2-(4-fluorophenyl)acetate (220437-99-0) + methyl iodide (74-88-4) → N,N-dimethyl-N-<(trimethylsilyl)methyl>-α-(methoxycarbonyl)-4-fluorobenzylammonium perchlorate

Guidance literature:

With sodium perchlorate; potassium carbonate; 1) MeCN, 12 h, 2) CHCl₃;

DOI:10.1021/jo981729h

Reference yield:

methyl 2-<(trimethylsilyl)methyl>amino-2-(4-fluorophenyl)acetate (220437-99-0) → methyl 3-(dimethylamino)-2-(4-fluorophenyl)propionate

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 1) K₂CO₃, 2) aq. NaClO₄ / 1) MeCN, 12 h, 2) CHCl₃

2: CsF / dimethylformamide / Ambient temperature

With sodium perchlorate; potassium carbonate; cesium fluoride; In N,N-dimethyl-formamide;

DOI:10.1021/jo981729h

upstream raw materials:

dl-α-4-fluorophenylglycine methyl ester hydrochloride

Chloromethyltrimethylsilane