N-[[6-Methoxy-2-(phenylmethoxy)-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-methylglycine Methyl Ester

Base Information

Chemical Name:N-[[6-Methoxy-2-(phenylmethoxy)-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-methylglycine Methyl Ester
CAS No.:125342-94-1
Molecular Formula:C₂₄H₂₂F₃NO₅
Molecular Weight:461.438
Hs Code.:

Synonyms:N-[[6-Methoxy-2-(phenylmethoxy)-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-methylglycine Methyl Ester

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Chemical Property of N-[[6-Methoxy-2-(phenylmethoxy)-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-methylglycine Methyl Ester

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Technology Process of N-[[6-Methoxy-2-(phenylmethoxy)-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-methylglycine Methyl Ester

There total 8 articles about N-[[6-Methoxy-2-(phenylmethoxy)-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-methylglycine Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 6-methoxy-2-(phenylmethoxy)-5-(trifluoromethyl)-1-naphthalenecarboxylic acid

: 79-37-8
oxalyl dichloride

: 13515-93-0
N-methylglycine methyl ester hydrochloride

: 125342-94-1
N-[[6-Methoxy-2-(phenylmethoxy)-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-methylglycine Methyl Ester

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: 2923-18-4
sodium 2,2,2-trifluoroacetate

: [(2-Benzyloxy-5-bromo-6-methoxy-naphthalene-1-carbonyl)-methyl-amino]-acetic acid methyl ester

: 125342-94-1
N-[[6-Methoxy-2-(phenylmethoxy)-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-methylglycine Methyl Ester

Guidance literature:: With copper(l) iodide; In various solvent(s); at 180 ℃; for 2.5h;
DOI:10.1021/jm00112a029

Reference yield:

: 50493-59-9
2-hydroxy-6-methoxynaphthalene-1-carbaldehyde

: 125342-94-1
N-[[6-Methoxy-2-(phenylmethoxy)-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-methylglycine Methyl Ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / 2 h / Heating

2: 1.) resorcinol, acetic acid, 2.) 80percent aq. sodium chlorite / 1.) p-dioxane, tert-butyl alcohol, 70 deg C, 2.) p-dioxane, tert-butyl alcohol, water, from 70 deg C to RT, 30 min

3: COCl₂ / dimethylformamide; CH₂Cl₂ / 1 h / Ambient temperature

4: Et₃N / tetrahydrofuran / 0.5 h / Ambient temperature

5: Br₂, HOAc

6: CuI / various solvent(s) / 2.5 h / 180 °C

With sodium chlorite; copper(l) iodide; bromine; potassium carbonate; acetic acid; triethylamine; recorcinol; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a029