cis/trans 1,1-dimethylethyl {1-[1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}carbamate

Base Information

• Chemical Name: cis/trans 1,1-dimethylethyl {1-[1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}carbamate
• CAS No.: 950772-65-3
• Molecular Formula: C₂₀H₃₈N₂O₃
• Molecular Weight: 354.533

Synonyms:cis/trans 1,1-dimethylethyl {1-[1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}carbamate

Chemical Property of cis/trans 1,1-dimethylethyl {1-[1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}carbamate

Chemical Property:

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Technology Process of cis/trans 1,1-dimethylethyl {1-[1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}carbamate

There total 5 articles about cis/trans 1,1-dimethylethyl {1-[1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

methylmagnesium bromide (75-16-1) + (piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → cis/trans 1,1-dimethylethyl {1-[1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}carbamate (950772-65-3)

Guidance literature:

tert‐butyl piperidin‐4‐ylcarbamate; 4-(propyloxy)cyclohexanone; With 1,2,3-triazole; In toluene; at 130 ℃; for 6h; Heating / reflux;

methylmagnesium bromide; In tetrahydrofuran; diethyl ether; toluene; at 0 - 25 ℃;

Reference yield: 30.0%

methylmagnesium bromide (75-16-1) + (piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) + 4-(propyloxy)cyclohexanone (158836-67-0) → cis/trans 1,1-dimethylethyl {1-[1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}carbamate (950772-65-3)

Guidance literature:

tert‐butyl piperidin‐4‐ylcarbamate; 4-(propyloxy)cyclohexanone; With 1,2,3-triazole; In toluene; at 130 ℃; for 6h;

methylmagnesium bromide; In tetrahydrofuran; diethyl ether; toluene; at 10 - 25 ℃;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; toluene; at 0 - 20 ℃;

Reference yield:

8-(propyloxy)-1,4-dioxaspiro[4.5]decane (950771-83-2) → cis/trans 1,1-dimethylethyl {1-[1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}carbamate (950772-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / tetrahydrofuran / 20 °C

1.2: pH 10 / Alkaline conditions

2.1: 1,2,3-triazole / toluene / 6 h / 130 °C

2.2: 10 - 25 °C

2.3: 0 - 20 °C

With 1,2,3-triazole; hydrogenchloride; water; In tetrahydrofuran; toluene;

upstream raw materials:

methylmagnesium bromide

(piperidin-4-yl)carbamic acid tert-butyl ester

4-(propyloxy)cyclohexanone

4,4-ethylenedioxycyclohexan-1-ol

Downstream raw materials:

cis N-(5-methyl-2-nitrophenyl)-1-[1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinamine

trans N-(5-methyl-2-nitrophenyl)-1-[1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinamine

(2-amino-5-methylphenyl){1-[cis-1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}amine

(2-amino-5-methylphenyl){1-[trans-1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}amine

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