(2S,3R)-1-[(tert-butyldimethylsilyl)oxy]-3-phenyl-2-(methanesulfonyloxy)butane

Base Information

Chemical Name:(2S,3R)-1-[(tert-butyldimethylsilyl)oxy]-3-phenyl-2-(methanesulfonyloxy)butane
CAS No.:197714-24-2
Molecular Formula:C₁₇H₃₀O₄SSi
Molecular Weight:358.574
Hs Code.:

Synonyms:(2S,3R)-1-[(tert-butyldimethylsilyl)oxy]-3-phenyl-2-(methanesulfonyloxy)butane

Suppliers and Price of (2S,3R)-1-[(tert-butyldimethylsilyl)oxy]-3-phenyl-2-(methanesulfonyloxy)butane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-1-[(tert-butyldimethylsilyl)oxy]-3-phenyl-2-(methanesulfonyloxy)butane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-1-[(tert-butyldimethylsilyl)oxy]-3-phenyl-2-(methanesulfonyloxy)butane

There total 6 articles about (2S,3R)-1-[(tert-butyldimethylsilyl)oxy]-3-phenyl-2-(methanesulfonyloxy)butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 124-63-0
methanesulfonyl chloride

: 197714-22-0
(2S,3R)-1-[(tert-butyldimethylsilyl)oxy]-3-phenyl-2-butanol

: 197714-24-2
(2S,3R)-1-[(tert-butyldimethylsilyl)oxy]-3-phenyl-2-(methanesulfonyloxy)butane

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 5h;
DOI:10.1021/jo971178f

Reference yield:

: 104196-23-8
(2S,3S)-2,3-epoxy-3-phenyl-1-propanol

: 197714-24-2
(2S,3R)-1-[(tert-butyldimethylsilyl)oxy]-3-phenyl-2-(methanesulfonyloxy)butane

Guidance literature:: Multi-step reaction with 5 steps

1.1: CuCN / diethyl ether / 1 h / -68 °C

1.2: 77 percent / diethyl ether / 3 h / -68 - 0 °C

2.1: 78 percent / imidazole / dimethylformamide / 24 h

3.1: 51 percent / PPh₃; diethyl azodicarboxylate / benzene / 12 h / 20 °C

4.1: 79 percent / DIBALH / CH₂Cl₂; hexane / 1 h / -20 °C

5.1: 89 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 5 h / 0 - 20 °C

With 1H-imidazole; dmap; diisobutylaluminium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; benzene; 1.1: transmetallation / 1.2: Ring cleavage / 2.1: silylation / 3.1: Mitsunobu reaction / 4.1: Reduction / 5.1: mesylation;
DOI:10.1021/jo971178f

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 197714-24-2
(2S,3R)-1-[(tert-butyldimethylsilyl)oxy]-3-phenyl-2-(methanesulfonyloxy)butane

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / imidazole / dimethylformamide / 24 h

2: 51 percent / PPh₃; diethyl azodicarboxylate / benzene / 12 h / 20 °C

3: 79 percent / DIBALH / CH₂Cl₂; hexane / 1 h / -20 °C

4: 89 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 5 h / 0 - 20 °C

With 1H-imidazole; dmap; diisobutylaluminium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In hexane; dichloromethane; N,N-dimethyl-formamide; benzene; 1: silylation / 2: Mitsunobu reaction / 3: Reduction / 4: mesylation;
DOI:10.1021/jo971178f