2-Piperidinecarboxamide,N-methyl-,(2R)-(9CI)

Base Information

• Chemical Name: 2-Piperidinecarboxamide,N-methyl-,(2R)-(9CI)
• CAS No.: 270258-76-9
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.201
• Mol file: 270258-76-9.mol

Synonyms:2-Piperidinecarboxamide,N-methyl-,(2R)-(9CI)

Chemical Property of 2-Piperidinecarboxamide,N-methyl-,(2R)-(9CI)

Chemical Property:

• PSA: 41.13000
• LogP: 0.59420

Purity/Quality:

99%min ^*data from raw suppliers

N-Methyl(R)-2-piperidinecarboxamide hydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Piperidinecarboxamide,N-methyl-,(2R)-(9CI)

There total 5 articles about 2-Piperidinecarboxamide,N-methyl-,(2R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl piperidine-2-carboxylate hydrochloride (32559-18-5) + methylamine (74-89-5) → N-methyl-2-piperidinecarboxamide (53941-92-7,207229-06-9,270258-76-9)

Guidance literature:

In water; at 25 ℃; for 18h;

Reference yield:

2-Methylcarbamoyl-piperidine-1-carboxylic acid benzyl ester → N-methyl-2-piperidinecarboxamide (53941-92-7,207229-06-9,270258-76-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0040-4039(97)01258-6

Reference yield:

N-benzyloxycarbonyl D/L-pipecolinic acid (28697-07-6) → N-methyl-2-piperidinecarboxamide (53941-92-7,207229-06-9,270258-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC

2: H₂ / Pd/C / methanol

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol;

DOI:10.1016/S0040-4039(97)01258-6

upstream raw materials:

methylamine

ethyl pipecolate

Tetrahydro-oxazolo[3,4-a]pyridine-1,3-dione

N-benzyloxycarbonyl D/L-pipecolinic acid

Refernces

• 1、 O'Neil, Ian A.,Potter, Andrew J.. "The highly stereoselective formation of pipecolic acid N-oxide and related derivatives". . p. 5731 - 5734. Retrieved 2007/10/03.