5-Bromo-3-Methoxy-Pyridine2-Carbonitrile

Base Information

• Chemical Name: 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile
• CAS No.: 36057-46-2
• Molecular Formula: C7H5BrN2O
• Molecular Weight: 213.033
• Hs Code.: 2933399090
• Mol file: 36057-46-2.mol

Synonyms:5-Bromo-3-Methoxy-Pyridine2-Carbonitrile;5-Bromo-3-methoxypicolinonitrile

Chemical Property of 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile

Chemical Property:

• Vapor Pressure: 0.000581mmHg at 25°C
• Refractive Index: 1.587
• Boiling Point: 310.9 °C at 760 mmHg
• PKA: -7.15±0.10(Predicted)
• Flash Point: 141.9 °C
• PSA: 45.91000
• Density: 1.65 g/cm³
• LogP: 1.72438
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-3-methoxy-pyridine2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

Useful:

Technology Process of 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile

There total 4 articles about 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-bromo-3-fluoropyridine-2-carbonitrile (886373-28-0) + sodium methylate (124-41-4) → 5-bromo-3-methoxy-pyridine-2-carbonitrile (36057-46-2)

Guidance literature:

In tetrahydrofuran; at 70 ℃; for 3h; Inert atmosphere;

Reference yield: 78.0%

methanol (67-56-1) + 5-bromo-3-nitropyridine-2-carbonitrile (573675-25-9) → 5-bromo-3-methoxy-pyridine-2-carbonitrile (36057-46-2)

Guidance literature:

With sodium methylate; for 8h; Reflux;

DOI:10.1016/j.bmcl.2014.05.003

Reference yield: 70.0%

5-bromo-3-nitropyridine-2-carbonitrile (573675-25-9) + sodium methylate (124-41-4) → 5-bromo-3-methoxy-pyridine-2-carbonitrile (36057-46-2)

Guidance literature:

In methanol; at 0 ℃; for 8h; Reflux;

upstream raw materials:

5-bromo-3-fluoropyridine-2-carbonitrile

sodium methylate

methanol

5-bromo-3-nitropyridine-2-carbonitrile

Downstream raw materials:

C₁₉H₁₄N₄O₄S

C₁₉H₁₄N₄O₄S

C₁₉H₁₆N₄O₃S

C₁₉H₁₆N₄O₃S

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