5-[1-Cyclohexyl-2-imidazol-1-yl-3-phenyl-prop-(E)-ylideneaminooxy]-pentanoic acid benzyloxy-amide

Base Information

Chemical Name:5-[1-Cyclohexyl-2-imidazol-1-yl-3-phenyl-prop-(E)-ylideneaminooxy]-pentanoic acid benzyloxy-amide
CAS No.:1025912-19-9
Molecular Formula:C₃₀H₃₈N₄O₃
Molecular Weight:502.657
Hs Code.:

Synonyms:5-[1-Cyclohexyl-2-imidazol-1-yl-3-phenyl-prop-(E)-ylideneaminooxy]-pentanoic acid benzyloxy-amide

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Chemical Property of 5-[1-Cyclohexyl-2-imidazol-1-yl-3-phenyl-prop-(E)-ylideneaminooxy]-pentanoic acid benzyloxy-amide

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Technology Process of 5-[1-Cyclohexyl-2-imidazol-1-yl-3-phenyl-prop-(E)-ylideneaminooxy]-pentanoic acid benzyloxy-amide

There total 5 articles about 5-[1-Cyclohexyl-2-imidazol-1-yl-3-phenyl-prop-(E)-ylideneaminooxy]-pentanoic acid benzyloxy-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 1027294-29-6
5-[1-Cyclohexyl-2-imidazol-1-yl-3-phenyl-prop-(E)-ylideneaminooxy]-pentanoyl chloride

: 1025912-19-9
5-[1-Cyclohexyl-2-imidazol-1-yl-3-phenyl-prop-(E)-ylideneaminooxy]-pentanoic acid benzyloxy-amide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 25 ℃; for 2h;
DOI:10.1021/jm00047a016

Reference yield:

: 14660-52-7
ethyl 5-bromovalerate

: 1025912-19-9
5-[1-Cyclohexyl-2-imidazol-1-yl-3-phenyl-prop-(E)-ylideneaminooxy]-pentanoic acid benzyloxy-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, RT, 2.) DMF, RT, 2 h

2: 60 percent / 1N aq. NaOH / ethanol / 4 h / Ambient temperature

3: SOCl₂ / CHCl₃ / 2 h / Ambient temperature

4: 89 percent / NaHCO₃ / tetrahydrofuran; H₂O / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; chloroform; water;
DOI:10.1021/jm00047a016

Reference yield:

: (+/-)-(E+Z)-1-cyclohexyl-2-(1H-imidazol-1-yl)-3-phenylpropan-1-one oxime

: 1025912-19-9
5-[1-Cyclohexyl-2-imidazol-1-yl-3-phenyl-prop-(E)-ylideneaminooxy]-pentanoic acid benzyloxy-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, RT, 2.) DMF, RT, 2 h

2: 60 percent / 1N aq. NaOH / ethanol / 4 h / Ambient temperature

3: SOCl₂ / CHCl₃ / 2 h / Ambient temperature

4: 89 percent / NaHCO₃ / tetrahydrofuran; H₂O / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; chloroform; water;
DOI:10.1021/jm00047a016