(R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide

Base Information

Chemical Name:(R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide
CAS No.:1438423-96-1
Molecular Formula:C₂₀H₁₉N₇O
Molecular Weight:373.417
Hs Code.:

Synonyms:(R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide

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Technology Process of (R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide

There total 5 articles about (R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82261-42-5
4-pyridin-3-ylaniline

: 1438423-93-8
(R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)butanamide

: 1438423-96-1
(R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide

Guidance literature:: With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 110 ℃; for 20h; Inert atmosphere;

Reference yield:

: 4282-46-6
3-(4'-nitrophenyl)pyridine

: 1438423-96-1
(R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 5 h

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; potassium carbonate / 1,4-dioxane / 20 h / 110 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; ethyl acetate;

Reference yield:

: 636-98-6
p-nitrobenzene iodide

: 1438423-96-1
(R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C

2: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 5 h

3: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; potassium carbonate / 1,4-dioxane / 20 h / 110 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; palladium diacetate; sodium carbonate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; water; ethyl acetate;