α-difluoromethyldiphenyl acetonitrile

Base Information

• Chemical Name: α-difluoromethyldiphenyl acetonitrile
• CAS No.: 1427-12-9
• Molecular Formula: C₁₅H₁₁F₂N
• Molecular Weight: 243.256
• Mol file: 1427-12-9.mol

Synonyms:α-difluoromethyldiphenyl acetonitrile

Chemical Property of α-difluoromethyldiphenyl acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-difluoromethyldiphenyl acetonitrile

There total 4 articles about α-difluoromethyldiphenyl acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trifluoromethan (75-46-7) + Diphenylacetonitrile (86-29-3) → α-difluoromethyldiphenyl acetonitrile (1427-12-9)

Guidance literature:

Diphenylacetonitrile; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h; Inert atmosphere;

trifluoromethan; In tetrahydrofuran; hexane; at -78 ℃; for 0.0166667h; Reagent/catalyst; Time; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02438

Reference yield: 43.0%

Chlorodifluoromethane (75-45-6) + Diphenylacetonitrile (86-29-3) → α-difluoromethyldiphenyl acetonitrile (1427-12-9)

Guidance literature:

Chlorodifluoromethane; Diphenylacetonitrile; With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In water; benzene; at 20 ℃; for 6h;

With isopropyl chloroacetate; N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In water; benzene; at 15 - 70 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2009.02.008

Reference yield:

Diphenylacetonitrile (86-29-3) + (trifluoromethyl)trimethylsilane (81290-20-2) → α-difluoromethyldiphenyl acetonitrile (1427-12-9) + 3,3-difluoro-2,2-diphenyl-3-(trimethylsilyl)propanenitrile

Guidance literature:

Diphenylacetonitrile; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h; Inert atmosphere;

(trifluoromethyl)trimethylsilane; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02438

upstream raw materials:

Chlorodifluoromethane

Diphenylacetonitrile

trifluoromethan

(trifluoromethyl)trimethylsilane

Downstream raw materials:

α-Difluormethyl-diphenylessigsaeure

Refernces

• 1、 Thomoson, Charles S.,Wang, Linhua,Dolbier, William R.. "Use of fluoroform as a source of difluorocarbene in the synthesis of N-CF2H heterocycles and difluoromethoxypyridines". . p. 34 - 39. Retrieved 2015/03/04.