C₂₁H₁₆F₄N₂O₃

Base Information

Chemical Name:C₂₁H₁₆F₄N₂O₃
CAS No.:1590403-80-7
Molecular Formula:C₂₁H₁₆F₄N₂O₃
Molecular Weight:420.363
Hs Code.:

C<sub>21</sub>H<sub>16</sub>F<sub>4</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:C₂₁H₁₆F₄N₂O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₁₆F₄N₂O₃

Chemical Property:

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Technology Process of C₂₁H₁₆F₄N₂O₃

There total 11 articles about C₂₁H₁₆F₄N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1590403-62-5
C₁₈H₁₂F₄N₂O₂

: 123-62-6
propionic acid anhydride

: 1590403-80-7
C₂₁H₁₆F₄N₂O₃

Guidance literature:: In toluene; Reflux;

Reference yield:

: 18677-43-5
2,4-dimethoxypyridine

: 1590403-80-7
C₂₁H₁₆F₄N₂O₃

Guidance literature:: Multi-step reaction with 9 steps

1: N-Bromosuccinimide / acetonitrile / 12 h / 70 - 85 °C / Darkness

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 10 h / 90 - 100 °C / Inert atmosphere

3: hydrogen bromide / water / 7 h / 100 °C

4: copper diacetate; pyridine N-oxide; pyridine; oxygen / dichloromethane / 38 h / 20 °C / Molecular sieve

5: boron tribromide / dichloromethane / 36 h / -70 - 30 °C

6: N,N-dimethyl-aniline; trichlorophosphate / dichloromethane / 2 h / 100 °C

7: 2.5 h / 180 °C / Inert atmosphere

8: trifluoroacetic acid / 3 h / 20 °C

9: toluene / Reflux

With pyridine; pyridine N-oxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; oxygen; copper diacetate; boron tribromide; potassium carbonate; N,N-dimethyl-aniline; trifluoroacetic acid; trichlorophosphate; In 1,2-dimethoxyethane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1590403-80-7
C₂₁H₁₆F₄N₂O₃

Guidance literature:: Multi-step reaction with 10 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 110 - 120 °C / Inert atmosphere

2: N-Bromosuccinimide / acetonitrile / 12 h / 70 - 85 °C / Darkness

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 10 h / 90 - 100 °C / Inert atmosphere

4: hydrogen bromide / water / 7 h / 100 °C

5: copper diacetate; pyridine N-oxide; pyridine; oxygen / dichloromethane / 38 h / 20 °C / Molecular sieve

6: boron tribromide / dichloromethane / 36 h / -70 - 30 °C

7: N,N-dimethyl-aniline; trichlorophosphate / dichloromethane / 2 h / 100 °C

8: 2.5 h / 180 °C / Inert atmosphere

9: trifluoroacetic acid / 3 h / 20 °C

10: toluene / Reflux

With pyridine; pyridine N-oxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; oxygen; copper diacetate; boron tribromide; potassium carbonate; N,N-dimethyl-aniline; trifluoroacetic acid; trichlorophosphate; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;