6-Hydroxybicyclo[2.2.1]heptane-2-carboxylic acid

Base Information

• Chemical Name: 6-Hydroxybicyclo[2.2.1]heptane-2-carboxylic acid
• CAS No.: 258345-33-4
• Molecular Formula: C₈H₁₂O₃
• Molecular Weight: 156.181
• DSSTox Substance ID: DTXSID60396350
• Mol file: 258345-33-4.mol

Synonyms:258345-33-4;6-hydroxybicyclo[2.2.1]heptane-2-carboxylic acid;Maybridge3_004395;Oprea1_817127;SCHEMBL6754701;DTXSID60396350;Bicyclo[2.2.1]heptane-2-carboxylic acid, 6-hydroxy- (9CI);HMS1443H17;IDI1_015782;CS-0119511;6-hydroxybicyclo[2.2.1]heptane-2-carboxylicacid;Bicyclo[2.2.1]heptane-2-carboxylic acid,6-hydroxy-(9ci)

Chemical Property of 6-Hydroxybicyclo[2.2.1]heptane-2-carboxylic acid

Chemical Property:

• PSA: 57.53000
• LogP: 0.47800
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 156.078644241
• Heavy Atom Count: 11
• Complexity: 190

Purity/Quality:

99% ^*data from raw suppliers

6-Hydroxybicyclo[2.2.1]heptane-2-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2CC(C1C(C2)O)C(=O)O

Technology Process of 6-Hydroxybicyclo[2.2.1]heptane-2-carboxylic acid

There total 16 articles about 6-Hydroxybicyclo[2.2.1]heptane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopentanone (120-92-3) + acrylic acid (79-10-7) + 6exo-Tosyloxy-2exo-norbornancarbonsaeure + methyl bicyclo[2.2.1]hept-5-ene-2-carboxylate (6203-08-3) → endo-norbornenecarboxylic acid (120-74-1,934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7) + exo-5-norbornene-2-carboxylic acid (934-30-5) + endo-norbornenecarboxylic acid (120-74-1,934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7) + exo-5-norbornene-2-carboxylic acid (934-30-5) + endo-norbornenecarboxylic acid (120-74-1,934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7) + carbomethoxy-2 exo hydroxy-6 exo bicyclo <2.2.1> heptane (22664-23-9,22664-24-0,33913-58-5,71358-94-6,258345-33-4,274690-02-7) + (1S,3R,6S,7S)-4-Oxa-tricyclo[4.2.1.03,7]nonan-5-one (6712-12-5,60133-51-9,68035-53-0) + (2R,6R)-Tricyclo[2.2.1.02,6]heptane-1-carboxylic acid

Guidance literature:

Multistep reaction; 2.) alkaline hydrolysis;

DOI:10.1007/BF00949621

Reference yield:

cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) + acrylic acid (79-10-7) + 6endo-Tosyloxy-2exo-norbornancarbonsaeure → exo-5-norbornene-2-carboxylic acid (934-30-5) + exo-5-norbornene-2-carboxylic acid (934-30-5) + carbomethoxy-2 exo hydroxy-6 exo bicyclo <2.2.1> heptane (22664-23-9,22664-24-0,33913-58-5,71358-94-6,258345-33-4,274690-02-7) + (1S,3R,6S,7S)-4-Oxa-tricyclo[4.2.1.03,7]nonan-5-one (6712-12-5,60133-51-9,68035-53-0) + (2R,6R)-Tricyclo[2.2.1.02,6]heptane-1-carboxylic acid

Guidance literature:

Reference yield:

6endo-Tosyloxy-2exo-norbornancarbonsaeure → endo-6-hydroxybicyclo<2.2.1>heptane-endo-2-carboxylic acid lactone (6712-12-5) + exo-5-norbornene-2-carboxylic acid (934-30-5) + carbomethoxy-2 exo hydroxy-6 exo bicyclo <2.2.1> heptane (22664-23-9,22664-24-0,33913-58-5,71358-94-6,258345-33-4,274690-02-7) + Tricyclo<2.2.1.02,6>heptan-2-carbonsaeure (697-25-6)

Guidance literature:

With water; triethylamine; In 1,4-dioxane; at 120 ℃; for 5.8h; Product distribution;

DOI:10.1002/hlca.19800630422

upstream raw materials:

exo-5-norbornene-2-carboxylic acid

methyl exo-5-norbornene-2-carboxylate

6-endo-tosyloxynorbornane-2-carboxylic acid sodium salt

6-exo-tosyloxynorbornane-2-carboxylic acid sodium salt

Downstream raw materials:

6endo-Hydroxy-2exo-norbornancarbonsaeure

6-exo-tosyloxy-2-endo-norbornancarbonsaeuremethylester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 258345-33-4 Bicyclo[2.2.1]heptane-2-carboxylic acid, 6-hydroxy- (9CI)

Send

Send

Metric Ton KG G Pound L ML

Send

Send