(S)-methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)-3-phenylpropanoate

Base Information

Chemical Name:(S)-methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)-3-phenylpropanoate
CAS No.:1363553-44-9
Molecular Formula:C₂₃H₂₅Cl₄NO₆
Molecular Weight:553.267
Hs Code.:

Synonyms:(S)-methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)-3-phenylpropanoate

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Chemical Property of (S)-methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)-3-phenylpropanoate

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Technology Process of (S)-methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)-3-phenylpropanoate

There total 4 articles about (S)-methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1363553-23-4
(S)-methyl 2-(5,6-dimethoxyisoindolin-2-yl)-3-phenylpropanoate

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 1363553-44-9
(S)-methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)-3-phenylpropanoate

Guidance literature:: In 1,2-dichloro-ethane; for 62h; Reflux; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.01.013

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 1363553-44-9
(S)-methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen bromide; acetic acid / 12 h / 20 °C / Inert atmosphere

2: potassium hydrogencarbonate / acetonitrile / 14.5 h / 20 °C / Inert atmosphere

3: 1,2-dichloro-ethane / 62 h / Reflux; Inert atmosphere

With hydrogen bromide; potassium hydrogencarbonate; acetic acid; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/j.tetlet.2012.01.013

Reference yield:

: 26726-81-8
1,2-bis(bromomethyl)-4,5-dimethoxybenzene

: 1363553-44-9
(S)-methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydrogencarbonate / acetonitrile / 14.5 h / 20 °C / Inert atmosphere

2: 1,2-dichloro-ethane / 62 h / Reflux; Inert atmosphere

With potassium hydrogencarbonate; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/j.tetlet.2012.01.013