p-Methoxyphenylacetaldoxim

Base Information

• Chemical Name: p-Methoxyphenylacetaldoxim
• CAS No.: 3353-51-3
• Molecular Formula: C9H11 N O2
• Molecular Weight: 165.192
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID801297159
• Mol file: 3353-51-3.mol

Synonyms:p-Methoxyphenylacetaldoxim;4-Methoxybenzeneacetaldehyde oxime;DTXSID801297159

Chemical Property of p-Methoxyphenylacetaldoxim

Chemical Property:

• PSA: 41.82000
• LogP: 1.69770
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 140

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 24-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC=NO

Technology Process of p-Methoxyphenylacetaldoxim

There total 14 articles about p-Methoxyphenylacetaldoxim which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-methoxy-4-(2-nitro-vinyl)-benzene (3179-10-0) → 2-(4-methoxyphenyl)acetaldehyde oxime (3353-51-3)

Guidance literature:

With hydrogen; In ethanol; at 60 ℃; for 0.75h; under 15001.5 Torr; chemoselective reaction; Autoclave;

DOI:10.1039/c6cc08505a

Reference yield: 83.0%

4-methoxyphenylacetylen (768-60-5) → 4-methoxyacetophenone oxime (2475-92-5) + 2-(4-methoxyphenyl)acetaldehyde oxime (3353-51-3)

Guidance literature:

With hydroxylamine; In 1,4-dioxane; water; at 113 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja806300r

Reference yield: 80.0%

4-Methoxyphenethylamine (55-81-2) → 2-(4-methoxyphenyl)acetaldehyde oxime (3353-51-3)

Guidance literature:

With sodium tungstate (VI) dihydrate; dihydrogen peroxide; In ethanol; water; at -10 ℃; for 24h;

DOI:10.1002/adsc.202101062

upstream raw materials:

4-Methoxyphenylacetaldehyde

ethanol

hydroxylamine acetate

(E)-1-methoxy-4-(2-nitrovinyl)benzene

Downstream raw materials:

4-Methoxyphenethylamine

3-(4-methoxy-phenyl)-quinoline-4-carboxylic acid

5-(4-methoxy-phenyl)-thiazolidine-2-thione

1,3-di(4'-methoxyphenethyl)thiourea