4-[6-cyclobutyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[6-cyclobutyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1331776-66-9
Molecular Formula:C₃₀H₄₁N₃O₄
Molecular Weight:507.673
Hs Code.:

Synonyms:4-[6-cyclobutyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[6-cyclobutyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[6-cyclobutyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester

There total 6 articles about 4-[6-cyclobutyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1331776-65-8
6-chloro-3-cyclobutyl-4-(4-cyclohexyloxyphenyl)pyridazine

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1331776-66-9
4-[6-cyclobutyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: t-butyl 4-hydroxy piperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h;

6-chloro-3-cyclobutyl-4-(4-cyclohexyloxyphenyl)pyridazine; In tetrahydrofuran; at 65 ℃; for 1h;

Reference yield:

: 108-93-0
cyclohexanol

: 1331776-66-9
4-[6-cyclobutyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: di-isopropyl azodicarboxylate / triphenylphosphine / tetrahydrofuran / 1.33 h / Inert atmosphere

2.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / 1 h / 130 °C / Microwave irradiation

3.1: triethylamine / toluene; tetrahydrofuran / 12 h / 20 °C

4.1: hydrazine hydrate; acetic acid / 1 h / 100 °C

5.1: trichlorophosphate / 0.33 h / 80 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

6.2: 1 h / 65 °C

With di-isopropyl azodicarboxylate; potassium tert-butylate; sodium hydride; hydrazine hydrate; acetic acid; triethylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triphenylphosphine; In tetrahydrofuran; toluene; mineral oil;

Reference yield:

: 30752-31-9
1-bromo-4-(cyclohexyloxy) benzene

: 1331776-66-9
4-[6-cyclobutyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / 1 h / 130 °C / Microwave irradiation

2.1: triethylamine / toluene; tetrahydrofuran / 12 h / 20 °C

3.1: hydrazine hydrate; acetic acid / 1 h / 100 °C

4.1: trichlorophosphate / 0.33 h / 80 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

5.2: 1 h / 65 °C

With potassium tert-butylate; sodium hydride; hydrazine hydrate; acetic acid; triethylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In tetrahydrofuran; toluene; mineral oil;